{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:47:01Z","timestamp":1791190021033,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GenMont Biotech Inc"},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 97-2314-B-192-001-MY2"],"award-info":[{"award-number":["NSC 97-2314-B-192-001-MY2"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of probiotics in the treatment of atopic dermatitis (AD) is not clearly established. Further clinical trials with new probiotic formulations are warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess the effects of\n                      <jats:italic>Lactobacillus paracasei<\/jats:italic>\n                      (LP) and\n                      <jats:italic>Lactobacillus fermentum<\/jats:italic>\n                      (LF), and their mixture on the disease severity, quality of life, and immune biomarkers of children with AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A double\u2010blind, prospective, randomized placebo\u2010controlled study was conducted on 220 children aged 1\u201318\u00a0years with moderate\u2010to\u2010severe AD (Trial number: NCT01635738). The children were randomized to receive LP, LF, LP\u00a0+\u00a0LF mixture, and placebo for 3\u00a0months. Changes in severity scoring of atopic dermatitis (SCORAD), Family Dermatology Life Quality Index (FDLQI), and Children's Dermatology Life Quality Index (CDLQI) scores in the different groups and at different visits were evaluated. Skin prick tests, levels of IgE, IFN\u2010\u03b3, IL\u20104, TGF\u2010\u03b2, and TNF\u2010\u03b1, and urine biomarkers were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children who received LP, LF, and LP\u00a0+\u00a0LF mixture showed lower SCORAD scores than the placebo group (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001), and this difference remained even at 4\u00a0months after discontinuing the probiotics. The FDLQI and CDLQI scores were lower in the LP, LF, and LP\u00a0+\u00a0LF mixture group than in the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02 and 0.03). IgE, TNF\u2010\u03b1, urine eosinophilic protein X, and 8\u2010OHdG levels decreased, whereas IFN\u2010\u03b3 and TGF\u2010\u03b2 increased in the probiotic groups, but these did not reach statistical significance except for IL\u20104 (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.04). In subgroup analyses, SCORAD scores significantly decreased after probiotic treatment especially in children younger than age 12, with breastfeeding &gt;\u00a06\u00a0months, and with mite sensitization (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Supplementation of a probiotic mixture of LP and LF is associated with clinical improvement in children with AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.12489","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T07:22:33Z","timestamp":1421738553000},"page":"779-787","source":"Crossref","is-referenced-by-count":119,"title":["Children with atopic dermatitis show clinical improvement after\n                    <i>Lactobacillus<\/i>\n                    exposure"],"prefix":"10.1111","volume":"45","author":[{"given":"I.\u2010J.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Taipei Hospital, Ministry of Health and Welfare Taipei Taiwan"},{"name":"College of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Health Risk Management China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine National Cheng Kung University Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00171"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01061.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/932391"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00958.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02513.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01543.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.060673"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00514.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_8_12_1","first-page":"1808","article-title":"Impact of patients\u2019 psoriasis on the quality of life of their families: initial results from a validation study of a novel dermatology\u2010specific measure","volume":"127","author":"Basra MKA","year":"2007","journal-title":"J Investig Dermatol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10996.x"},{"key":"e_1_2_8_14_1","unstructured":"Duotip\u2010Test\u00ae II Package Insert \u2013 Alk.2006. 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