{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:20:02Z","timestamp":1790850002045,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000774","name":"University of Newcastle","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral corticosteroids (OCS) are an efficacious treatment for asthma exacerbations, yet risk of adverse effects may decrease patient adherence to therapy. In particular, changes in appetite and dietary intake, which lead to weight gain and changes in body composition, are considered undesirable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether 10\u2010day OCS therapy in adults with asthma causes changes in leptin, appetite, dietary intake, body weight and body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Double\u2010blinded, placebo\u2010controlled randomized cross\u2010over trial of 10\u00a0days prednisolone (50\u00a0mg) in adults with stable asthma (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) (ACTRN12611000562976). Pre\u2010 and post\u2010assessment included spirometry, body weight, body composition measured by dual\u2010energy X\u2010ray absorptiometry and bioelectrical impedance analysis, appetite measured using a validated visual analogue scale (VAS) and dietary intake assessed using 4\u2010day food records. Leptin was measured as a biomarker of appetite and eosinophils as an adherence biomarker. Outcomes were analysed by generalized linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subject adherence was confirmed by a significant decrease in blood eosinophils (\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) following prednisolone compared to placebo [Coef. \u22120.29, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (\u22120.39, \u22120.19) <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. There was no difference in serum leptin (ng\/mL) [Coef. 0.13, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (\u22123.47, 3.72) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.945] or appetite measured by VAS (mm) [Coef. \u22124.93, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (\u221213.64, 3.79) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.267] following prednisolone vs. placebo. There was no difference in dietary intake (kJ\/day) [Coef. 255, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (\u2212380, 891) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.431], body weight (kg) [Coef. \u22120.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (\u22120.81, 0.05) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.083] or body fat (%) [Coef. \u22120.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (\u22120.81, 0.20) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.230]. Symptoms including sleep and gastrointestinal disturbance were reported significantly more often during prednisolone vs. placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Short\u2010term OCS in stable asthma did not induce significant changes in appetite, dietary intake, body weight or composition, although other adverse effects may require medical management. This evidence may assist in increasing medication adherence of asthmatics prescribed OCS for exacerbations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12505","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T09:18:58Z","timestamp":1422782338000},"page":"908-919","source":"Crossref","is-referenced-by-count":19,"title":["Effects of short\u2010term oral corticosteroid intake on dietary intake, body weight and body composition in adults with asthma \u2013 a randomized controlled trial"],"prefix":"10.1111","volume":"45","author":[{"given":"B. S.","family":"Berthon","sequence":"first","affiliation":[{"name":"Centre for Asthma and Respiratory Disease Hunter Medical Research Institute University of Newcastle Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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