{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:16:52Z","timestamp":1775841412956,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cociencias","award":["540\u20132008"],"award-info":[{"award-number":["540\u20132008"]}]},{"DOI":"10.13039\/100007637","name":"Colciencias","doi-asserted-by":"crossref","award":["602-2009"],"award-info":[{"award-number":["602-2009"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm <jats:italic>Ascaris<\/jats:italic> or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between the IgE responses to <jats:italic>Ascaris<\/jats:italic> and its purified allergens and the risk of asthma in a tropical country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested case\u2013control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to <jats:italic>Ascaris<\/jats:italic> extract, Asc s 1 (<jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content>\u20101), Asc l 3 (tropomyosin) and <jats:styled-content style=\"fixed-case\">GST<\/jats:styled-content> (glutathione transferase). In addition, specific IgE to <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>,<jats:italic> Blomia tropicalis<\/jats:italic> and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sensitization to <jats:italic>Ascaris<\/jats:italic> and <jats:italic>D. pteronyssinus<\/jats:italic> was independently associated with asthma after adjustment for age, gender, socio\u2010economic stratum, city and other IgE levels (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s: 2.17; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.37\u20133.42 and 2.46; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.54\u20133.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross\u2010reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>s: 1.76; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.21\u20132.57, 1.64; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.14\u20132.35 and 1.51; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.02\u20132.24), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>IgE responses to <jats:italic>Ascaris<\/jats:italic> are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross\u2010reactive <jats:italic>Ascaris<\/jats:italic> and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12513","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T13:25:10Z","timestamp":1424352310000},"page":"1189-1200","source":"Crossref","is-referenced-by-count":68,"title":["IgE responses to <i>Ascaris<\/i> and mite tropomyosins are risk factors for asthma"],"prefix":"10.1111","volume":"45","author":[{"given":"V.","family":"Ahumada","sequence":"first","affiliation":[{"name":"Institute for Immunological Research University of Cartagena Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Otorhinolaryngology Fundaci\u00f3n Santaf\u00e9 de Bogot\u00e1 Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Cardioinfantil \u2013 Instituto de Cardiolog\u00eda Bogot\u00e1 Colombia"},{"name":"Department of Clinical Epidemiology and Biostatistics School of Medicine Pontificia Universidad Javeriana Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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