{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:23:26Z","timestamp":1791933806147,"version":"4.3.4"},"reference-count":89,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The prevalence of A<\/jats:styled-content>spergillus<\/jats:italic> sensitization (AS<\/jats:styled-content>) and allergic bronchopulmonary aspergillosis (ABPA<\/jats:styled-content>) in cystic fibrosis (CF<\/jats:styled-content>) has been varyingly reported. The aim of this systematic review was to estimate the overall prevalence of AS<\/jats:styled-content>\/ABPA<\/jats:styled-content> in CF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We searched the PubMed and EmBase databases for studies reporting the prevalence of AS<\/jats:styled-content>\/ABPA<\/jats:styled-content> in CF<\/jats:styled-content>. We calculated the proportion with 95% confidence interval (CI<\/jats:styled-content>) to assess the prevalence of AS<\/jats:styled-content> and ABPA<\/jats:styled-content> in the individual studies and then pooled the results using a random effects model. Statistical heterogeneity was assessed using the I<\/jats:italic>2<\/jats:sup> test while publication bias was assessed using both graphical and statistical methods.<\/jats:p><\/jats:sec>Results<\/jats:title>Our search yielded 64 eligible studies. The pooled prevalence of AS<\/jats:styled-content> was 39.1% (95% CI<\/jats:styled-content>: 33.3\u201345.1) and was higher with skin test compared to specific IgE (43.8% vs. 32.8%, P<\/jats:italic>\u00a0=\u00a00.002); however, the prevalence did not vary with the type of skin test used (intradermal or percutaneous). The prevalence of ABPA<\/jats:styled-content> was 8.9% (95% CI<\/jats:styled-content>: 7.4\u201310.7) and was higher in adults as compared to children (10.1% vs. 8.9%, P<\/jats:italic>\u00a0<\u00a00.0001). There was a wide variation in the criteria used for diagnosing ABPA<\/jats:styled-content>. Almost 50% (12\/23) of the publications after 2004 used criteria other than the CF<\/jats:styled-content> foundation criteria for diagnosing ABPA<\/jats:styled-content>. There was significant statistical heterogeneity and evidence of publication bias.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There is a high prevalence of AS<\/jats:styled-content> and ABPA<\/jats:styled-content> in patients with CF<\/jats:styled-content>. Despite six decades of research, there is still a need to adopt uniform methodology and criteria for the diagnosis of AS<\/jats:styled-content>\/ABPA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12595","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:03:12Z","timestamp":1436886192000},"page":"1765-1778","source":"Crossref","is-referenced-by-count":163,"title":["Prevalence of A<\/scp>spergillus<\/i> sensitization and allergic bronchopulmonary aspergillosis in cystic fibrosis: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"45","author":[{"given":"V. 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