{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:17:42Z","timestamp":1790471862192,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mastocytosis is difficult to diagnose, especially when systemic mast cell activation symptoms are not present or involve only one extracutaneous organ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The main objective was to evaluate the accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis in patients with a clinical suspicion of mastocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all adult patients evaluated in our centre between December 2009 and 2013 for suspected mastocytosis as part of a standardized procedure and who had a bone marrow and serum tryptase assay on the same day. The diagnosis of systemic mastocytosis was established on the basis of the World Health Organization criteria as the gold standard. The accuracy of the bone marrow tryptase level in the diagnosis of systemic mastocytosis was assessed by a receiver operating characteristics curve analysis. The different sensitivity and specificity values, corresponding to the set of possible bone marrow tryptase level cut\u2010off values, were estimated with 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients were included. The diagnosis of systemic mastocytosis was established in 43 patients (58.9%). The median bone marrow tryptase level was 423\u00a0\u03bcg\/L [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 217\u2013868] in the systemic mastocytosis group and 7.5\u00a0\u03bcg\/L [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 4.6\u201317.1] in the non\u2010systemic mastocytosis group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). A cut\u2010off value of 50\u00a0\u03bcg\/L for bone marrow tryptase identified systemic mastocytosis with a sensitivity of 93.0% [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 80.9\u201398.5%] and a specificity of 90.0% [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 73.5\u201397.9%].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>The bone marrow tryptase level appears to be a valuable diagnostic criterion for confirming systemic mastocytosis. If this diagnosis can reliably be excluded by evaluation of the bone marrow tryptase level, there would be no need to perform a bone marrow biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12627","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T08:54:53Z","timestamp":1440665693000},"page":"133-141","source":"Crossref","is-referenced-by-count":12,"title":["Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis"],"prefix":"10.1111","volume":"46","author":[{"given":"C.","family":"Bulai Livideanu","sequence":"first","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Dermatology Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Apoil","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Immunology Clinical Laboratory Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lepage","sequence":"additional","affiliation":[{"name":"USMR Support Unit for Research Methodology Department of Epidemiology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eischen","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Rheumatology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Laurent","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Anatomy and Pathological Cytology of Prof. Brousset Cancer University Institute of Toulouse Oncopole Toulouse 6 Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Laharrague","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Hematology Clinical Laboratory Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lamant","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Anatomy and Pathological Cytology of Prof. Brousset Cancer University Institute of Toulouse Oncopole Toulouse 6 Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tournier","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Anatomy and Pathological Cytology of Prof. Brousset Cancer University Institute of Toulouse Oncopole Toulouse 6 Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tavitian","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Hematology Toulouse University Institute of Cancer\u2010Oncopole Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pouplard","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Dermatology Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Recher","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Hematology Toulouse University Institute of Cancer\u2010Oncopole Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Laroche","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Rheumatology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mailhol","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Pneumo\u2010allergology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dubreuil","sequence":"additional","affiliation":[{"name":"CRCM, [Signaling, Hematopoiesis and Mechanism of Oncogenesis], Inserm, U1068 Marseille France"},{"name":"Institut Paoli\u2010Calmettes; Aix\u2010Marseille University, UM105, CNRS, UMR7258 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Hermine","sequence":"additional","affiliation":[{"name":"CEREMAST Department of Hematology Necker Hospital Paris\u2010APH Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Blancher","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Immunology Clinical Laboratory Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Paul","sequence":"additional","affiliation":[{"name":"Mastocytosis Expert Center of Midi\u2010Pyr\u00e9n\u00e9es Department of Dermatology Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00038-8"},{"key":"e_1_2_8_3_1","unstructured":"ArockM.Systemic Mastocytosis. 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