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Recent studies suggest staphylococcal enterotoxin IgE (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE) sensitization to be a risk factor for asthma in general populations; however, the associations have not been examined in late\u2010onset elderly asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to examine the associations of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE sensitization with late\u2010onset asthma in the elderly, using a database of elderly asthma cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 249 elderly patients with asthma and 98 controls were analysed. At baseline, patients were assessed for demographics, atopy, induced sputum profiles and comorbidities including chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>). Serum total IgE and <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE levels were measured. Asthma severity was assessed on the basis of asthma outcomes during a 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, serum <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE concentrations were significantly higher in patients with asthma than in controls [median 0.16 (interquartile range 0.04\u20130.53) vs. 0.10 (0.01\u20130.19), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. Elderly asthma patients with high <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE levels had specific characteristics of having more severe asthma, sputum eosinophilia and <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>, compared to those with lower <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE levels. In multivariate logistic regression analyses, the associations between serum <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE concentrations and severe asthma were significant, independently of covariables [<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE\u2010high (\u2265\u00a00.35\u00a0kU\/L) vs. negative (&lt;\u00a00.10\u00a0kU\/L) group: odds ratio 7.47, 95% confidence interval 1.86\u201330.03, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005]. Multiple correspondence analyses also showed that high serum <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE level had close relationships with severe asthma, <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and sputum eosinophilia together.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>This is the first report on the significant associations of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\u2010IgE sensitization with late\u2010onset asthma in the elderly, particularly severe eosinophilic asthma with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> comorbidity. Our findings indicate a potential implication of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> in the high morbidity burden of elderly asthma and suggest clues to the pathogenesis of severe late\u2010onset eosinophilic asthma in the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12652","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T16:28:33Z","timestamp":1444062513000},"page":"411-421","source":"Crossref","is-referenced-by-count":66,"title":["Staphylococcal enterotoxin IgE sensitization in late\u2010onset severe eosinophilic asthma in the elderly"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-9922","authenticated-orcid":false,"given":"W.\u2010J.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sintobin","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010H.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010G.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010K.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.\u2010J.","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine Pusan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine Pusan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine SMG\u2010SNU Boramae Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010K.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine Pusan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u00a0E.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chosun University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010W.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010S.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u2010J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010K.","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dankook University College of Medicine Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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