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The relationships between smoking cigarette and both <jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> and B\u2010eos are complex and raise questions about the association between these markers and asthma in smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the relationships between both <jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> and B\u2010eos on one hand and asthma and atopy on the other, according to smoking status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> and B\u2010eos were measured in, respectively, 1579 and 1496 of the 1607 middle\u2010aged adults randomly selected from the general population in the cross\u2010sectional <jats:styled-content style=\"fixed-case\">ELISABET<\/jats:styled-content> survey. Allergic asthma was defined as asthma (a self\u2010report of physician\u2010diagnosed asthma, and wheezing in the previous 12\u00a0months or the use of asthma medications) with atopy (allergic rhinitis or hayfever in the previous 12\u00a0months, or a previous positive prick test or allergen desensitization therapy). Non\u2010allergic asthma was defined as asthma without atopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 812 (51.4%) never, 473 (30%) former and 294 (18.6%) current smokers. A total of 490 (32%) participants were atopic, 80 (5.1%) had allergic asthma, and 31 (2%) had non\u2010allergic asthma. Only 16.2% (18\/111) of asthmatics were treated with glucocorticoid inhalants, suggesting that among them a majority of participants had mild asthma. A positive interaction between smoking status and allergic asthma was observed in multivariate models explaining <jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and B\u2010eos (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Thus, compared to those without allergic asthma, participants with allergic asthma had higher <jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> values (+\u00a063.4%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a0[39; 92]) and higher B\u2010eos (+\u00a063.2% [38.2; 92.7]) in never and former smokers, but not in current smokers. Lastly, an analysis of receiver\u2010operating characteristic curves showed that each of the two markers was able to discriminate moderately allergic asthma but only in non\u2010smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Clinical Relevance<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> and B\u2010eos were associated with the presence of mild allergic asthma only in non\u2010smokers, not in current smokers. These findings raise questions about the clinical value of <jats:styled-content style=\"fixed-case\">FENO<\/jats:styled-content> and B\u2010eos in smokers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12669","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T03:58:42Z","timestamp":1446782322000},"page":"543-554","source":"Crossref","is-referenced-by-count":23,"title":["Both exhaled nitric oxide and blood eosinophil count were associated with mild allergic asthma only in non\u2010smokers"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-4670","authenticated-orcid":false,"given":"J.","family":"Giovannelli","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Henri Warembourg University of Lille Lille Cedex France"},{"name":"University Hospital of Lille Lille France"},{"name":"Pasteur Institute of Lille INSERM U1167 RID\u2010AGE Lille 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