{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:34:56Z","timestamp":1776720896712,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010ALIA\u20102012"],"award-info":[{"award-number":["ANR\u201010\u2010ALIA\u20102012"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">MIRABEL<\/jats:styled-content> survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to study the presence of peanut traces in pre\u2010packed foods with\/without precautionary allergen labelling (<jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>), and to combine these data to quantify allergic risk and produce a cost\/benefit analysis. This paper reports a real\u2010life observatory of 785 patients (&lt;\u00a016y: 86%): medical characteristics, eliciting doses (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) in real life and in oral food challenges (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>), factors associated with severe reactions, allergist dietary advice and patients\u2019 anxiety regarding their allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Age and symptoms at diagnosis, route of exposure, comorbidities, allergy tests, <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>\/real life; mg peanut protein), dietary advice about <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>, and anxiety score were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 3\u00a0years; 85% were declared allergic. Severe\/potentially severe reactions were reported in 30% of the allergic patients: serious systemic reaction (15%), laryngeal angioedema (8%), shock (4%) and acute asthma (3%); 66% had atopic dermatitis, 58% asthma. Median ara h 2 <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> level was 11.5\u00a0kUA\/L. Of the 278 <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>s, 225 were positive (median <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>: 67.3 mg). Real\u2010life <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> was &lt;\u00a0100\u00a0mg in 44.3%. Severe reactions were significantly more frequent in teenagers and adults (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), asthmatic patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.033), and patients who reacted to inhalation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). No significant association was found for <jats:styled-content style=\"fixed-case\">OFC ED<\/jats:styled-content> or ara h 2 <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>. Factors associated with strict avoidance advice including <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content> were <jats:styled-content style=\"fixed-case\">OFC ED<\/jats:styled-content> &lt;\u00a0100\u00a0mg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not severe reaction history (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.051) or asthma (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.34). Anxiety was significantly associated with strict avoidance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Severe\/potentially severe reactions, allergic comorbidities, and low <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>s in real life are frequent in peanut\u2010allergic patients. Asthma, teenage\/adulthood and reaction to inhalation are associated with severe symptoms. <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content> and criteria guiding dietary advice need to be improved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12681","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T16:10:10Z","timestamp":1448035810000},"page":"610-620","source":"Crossref","is-referenced-by-count":83,"title":["Peanut\u2010allergic patients in the <scp>MIRABEL<\/scp> survey: characteristics, allergists\u2019 dietary advice and lessons from real life"],"prefix":"10.1111","volume":"46","author":[{"given":"A.","family":"Deschildre","sequence":"first","affiliation":[{"name":"CHU Lille Pediatric Pulmonology and Allergy Department h\u00f4pital Jeanne de Flandre Lille France"},{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F.","family":"Elegb\u00e9d\u00e9","sequence":"additional","affiliation":[{"name":"Risk Assessment Department (DER) French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES) Maisons\u2010Alfort France"},{"name":"French National Institute for Agricultural Research (INRA) Paris Institute of Technology for Life, Food and Environmental Sciences (AgroParisTech) UMR Economie Publique INRA\u2010AgroParisTech Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Just","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Allergology Department Centre de l'Asthme et des Allergies H\u00f4pital d'Enfants Armand\u2010Trousseau, APHP; Sorbonne Universit\u00e9s, UPMC Univ Paris 06 INSERM UMR_S 1136 Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique Equipe EPAR Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Bruy\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology and Health Economics University of Li\u00e8ge CHU Sart Tilman Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Van der Brempt","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Allergop\u00f4le Clinique Saint\u2010Luc Bouge (Namur) Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Risk Assessment Department (DER) French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES) Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Beaudouin","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Allergy Department Centre Hospitalier E Durkhe\u00efm Epinal France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. \u2010M.","family":"Renaudin","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Allergy Department Centre Hospitalier E Durkhe\u00efm Epinal France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Crepet","sequence":"additional","affiliation":[{"name":"Risk Assessment Department (DER) French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES) Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010A.","family":"Moneret\u2010Vautrin","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Allergy Department Centre Hospitalier E Durkhe\u00efm Epinal France"},{"name":"Lorraine University Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12423"},{"key":"e_1_2_9_3_1","first-page":"54","article-title":"Prevalence of peanut sensitization in a population of 4737 subjects\u2013an Allergo\u2010Vigilance Network enquiry carried out in 2002","volume":"37","author":"Morisset M","year":"2005","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12178"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-7-10"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.12.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03120.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01968.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_9_13_1","unstructured":"ANSES2013:Table\u00a0de composition nutritionnelle des aliments Ciqual. Available athttps:\/\/pro.anses.fr\/TableCIQUAL\/"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114708"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00305.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321108"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.allerg.2006.08.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03717.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00149812"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.037"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1569"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.051"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.050"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03954.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60835-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2012.08.007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.053"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12075"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.035"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.013"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02312.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01310.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12582"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12466"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.10.032"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.042"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12614"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12681","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:52:59Z","timestamp":1696384379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,29]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/cea.12681"],"URL":"https:\/\/doi.org\/10.1111\/cea.12681","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,29]]}}}