{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:34:47Z","timestamp":1787614487756,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200001"],"award-info":[{"award-number":["81200001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Several clinical and experimental studies have implicated IL<\/jats:styled-content>\u201033 and its receptor ST<\/jats:styled-content>2 in the development of asthma. However, the effect of IL<\/jats:styled-content>\u201033\/ST<\/jats:styled-content>2 signalling on airway responses and inflammation in allergic asthma is not well established.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the role of IL<\/jats:styled-content>\u201033\/ST<\/jats:styled-content>2 signalling in promoting allergen\u2010induced airway hyperresponsiveness (AHR<\/jats:styled-content>), airway inflammation, antigen\u2010specific IgE production and mast cell activity in a mouse model of asthma.<\/jats:p><\/jats:sec>Methods<\/jats:title>ST<\/jats:styled-content>2\u2010deficient (ST<\/jats:styled-content>2\u2212\/\u2212<\/jats:sup>) mice and control BALB<\/jats:styled-content>\/c mice were given house dust mite (HDM<\/jats:styled-content>) extract over a 6\u2010week period. Forty\u2010eight hours after the final HDM<\/jats:styled-content> administration, lung function and airway inflammation were evaluated. Airway responsiveness was determined in the central airways and peripheral lung. Cellular infiltration and mast cell protease mMCP<\/jats:styled-content>\u20101 levels were quantified in bronchoalveolar lavage fluid (BALF<\/jats:styled-content>). Recruitment of inflammatory cells and inflammatory cytokine profiles were assessed in pulmonary tissue, and HDM<\/jats:styled-content>\u2010specific IgE was measured in serum.<\/jats:p><\/jats:sec>Results<\/jats:title>ST<\/jats:styled-content>2 deficiency diminished HDM<\/jats:styled-content>\u2010induced AHR<\/jats:styled-content> in the peripheral lung, while AHR<\/jats:styled-content> in the central airways was unaffected. Inflammatory responses to HDM<\/jats:styled-content> were also reduced in ST<\/jats:styled-content>2\u2212\/\u2212<\/jats:sup> mice as reflected by the lower induction of HDM<\/jats:styled-content>\u2010specific serum IgE, inhibition of HDM<\/jats:styled-content>\u2010induced eosinophilia and reduced macrophage count in BALF<\/jats:styled-content>, and a diminished influx of inflammatory cells and reduced goblet cell hyperplasia around the peripheral airways. Furthermore, the levels of the inflammatory cytokines IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20105, IL<\/jats:styled-content>\u201013, IL<\/jats:styled-content>\u201033, GM<\/jats:styled-content>\u2010CSF<\/jats:styled-content>, thymic stromal lymphopoietin and mast cell protease mMCP<\/jats:styled-content>\u20101 were reduced in HDM<\/jats:styled-content>\u2010treated ST<\/jats:styled-content>2\u2212\/\u2212<\/jats:sup> mice compared with wild\u2010type controls.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In addition to promoting Th2 inflammation, we now suggest a role for the IL<\/jats:styled-content>\u201033\/ST<\/jats:styled-content>2 pathway for the induction of peripheral inflammation and mucus production that causes AHR<\/jats:styled-content> in the peripheral lung. This mechanism for inducing AHR<\/jats:styled-content> at distal parts of the lung may be of specific importance as asthma is considered as a small airway disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12683","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T15:44:58Z","timestamp":1448552698000},"page":"479-490","source":"Crossref","is-referenced-by-count":60,"title":["The interleukin\u201033 receptor ST<\/scp>2 is important for the development of peripheral airway hyperresponsiveness and inflammation in a house dust mite mouse model of asthma"],"prefix":"10.1111","volume":"46","author":[{"given":"A. M.","family":"Zoltowska","sequence":"first","affiliation":[{"name":"Clinical Immunology and Allergy Unit Department of Medicine Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lei","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Unit Department of Medicine Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Pharmacy The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Unit Department of Medicine Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"},{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rask","sequence":"additional","affiliation":[{"name":"ALK\u2010Abell\u00f3 Hoersholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Adner","sequence":"additional","affiliation":[{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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