{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:44:53Z","timestamp":1787262293464,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds","doi-asserted-by":"publisher","award":["B\/11005\/02"],"award-info":[{"award-number":["B\/11005\/02"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The majority of grass pollen\u2013sensitized rhinitis patients develops allergic symptoms when exposed to the causal allergen and shows a positive nasal allergen provocation test (<jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>). Chronic rhinosinusitis with nasal polyposis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>) patients, also characterized by eosinophilic inflammation and local IgE production, can suffer from comorbid inhalant allergy, but may show a different response to allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to explore the allergic response to grass pollen allergens by <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content> in grass pollen\u2013sensitized <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve grass pollen\u2013sensitized <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> patients underwent <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content> with grass pollen and were compared with 12 grass pollen allergic rhinitis patients, 12 control patients and 12 <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> patients without grass pollen sensitization. A positive <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content> was based on change in nasal airflow and symptoms. Further, <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores of different symptoms were noted before and after <jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content>. Biomarkers such as total IgE, grass pollen\u2013specific IgE and tryptase were measured in serum and nasal secretions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAPT<\/jats:styled-content> was positive in 6 of 12 of the grass pollen\u2013sensitized <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> patients, and another four patients developed allergic symptoms not fulfilling the criteria of positivity. In contrast, all patients with allergic rhinitis developed a positive provocation test, whereas in the control group one of the patients and in the non\u2010sensitized <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> group two of the patients developed a positive provocation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>These results show that allergen exposure induces an attenuated clinical response in patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> and sensitization to grass pollen as compared with grass pollen allergic rhinitis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12687","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T07:42:48Z","timestamp":1449992568000},"page":"555-563","source":"Crossref","is-referenced-by-count":13,"title":["The response to nasal allergen provocation with grass pollen is reduced in\u00a0patients with chronic rhinosinusitis with nasal polyposis and grass sensitization"],"prefix":"10.1111","volume":"46","author":[{"given":"L.","family":"Calus","sequence":"first","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Devuyst","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Van 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