{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:28:27Z","timestamp":1787311707218,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Severance Regional Pharmacovigilance Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Histamine H\n                      <jats:sub>2<\/jats:sub>\n                      receptor antagonists are commonly prescribed medications and are known to be well tolerated. However, 99 cases of ranitidine\u2010induced anaphylaxis occurred in Korea from 2007 to 2014.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to determine the incidence, clinical features, and diagnostic methods for ranitidine\u2010induced anaphylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ranitidine\u2010related pharmacovigilance data from 2007 to 2014 were reviewed. Adverse drug reactions with causal relationships were selected, and clinical manifestations, outcomes, and drug\u2010related information were assessed. For further investigation, 8\u00a0years of pharmacovigilance data were collected at a single centre. Twenty\u2010three patients participated in\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      and\n                      <jats:italic>in\u00a0vitro<\/jats:italic>\n                      studies. Skin tests, oral provocation tests, and laboratory tests were performed, including tests using other kinds of histamine H\n                      <jats:sub>2<\/jats:sub>\n                      receptor antagonists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over 7\u00a0years, 584 patients suffered adverse reactions to ranitidine. The most common manifestation was cutaneous symptoms. Among them, 99 patients (17.0%) experienced anaphylaxis. In a single\u2010centre study, skin prick tests were positive in 91.7% of ranitidine\u2010induced anaphylaxis patients (11\/12); the optimal concentration was 20\u00a0mg\/mL. Detection of ranitidine\u2010specific immunoglobulin E failed. Cimetidine and proton pump inhibitors showed no cross\u2010reactivity with ranitidine based on the skin prick test, oral provocation test, or clinical determination. Surprisingly, 82.6% of patients reintroduced ranitidine and re\u2010experienced the same adverse reactions because ranitidine was not considered the culprit drug.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Although ranitidine is known as a safe drug, it can also cause diverse adverse reactions, including anaphylaxis. This study demonstrates the need to pay attention to adverse reactions to ranitidine and consider ranitidine as a cause of anaphylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.12708","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T14:27:08Z","timestamp":1452781628000},"page":"631-639","source":"Crossref","is-referenced-by-count":27,"title":["Ranitidine\u2010induced anaphylaxis: clinical features, cross\u2010reactivity, and skin testing"],"prefix":"10.1111","volume":"46","author":[{"given":"K. H.","family":"Park","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Allergy Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010G.","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of Biomodulation KIST Gangneung Institute of Natural Products Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Sim","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Allergy Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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