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Constitutive factors such as age, height and gender, as well as individual characteristics, such as IgE sensitization and smoking, affect the levels of FeNO in population\u2010based studies. However, their effect on FeNO in subjects with asthma has been scarcely studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the effects on FeNO of these commonly regarded determinants, as demonstrated in healthy subjects, as well as menarche age and parental smoking, in a population of asthmatics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fractional exhaled nitric oxide was measured in 557 subjects with asthma from the Swedish <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content><jats:sup>2<\/jats:sup><jats:styled-content style=\"fixed-case\">LEN<\/jats:styled-content> study. Allergic sensitization was assessed by skin prick tests to most common aeroallergens. Upper airway comorbidities, smoking habits, smoking exposure during childhood and hormonal status (for women) were questionnaire\u2010assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Male gender (<jats:italic>P<\/jats:italic> &lt; 0.001), greater height (<jats:italic>P<\/jats:italic> &lt; 0.001) and sensitization to both perennial allergens and pollen (<jats:italic>P<\/jats:italic> &lt; 0.001) are related to higher FeNO levels. Current smoking (<jats:italic>P<\/jats:italic> &lt; 0.001) and having both parents smoking during childhood, vs. having neither (<jats:italic>P<\/jats:italic> &lt; 0.001) or only one parent smoking (<jats:italic>P<\/jats:italic> = 0.002), are related to lower FeNO. Women with menarche between 9 and 11 years of age had lower FeNO than those with menarche between 12 and 14 years of age (<jats:italic>P<\/jats:italic> = 0.03) or 15 and 17 years of age (<jats:italic>P<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical relevance<\/jats:title><jats:p>Interpreting FeNO levels in clinical practice is complex, and constitutional determinants, as well as smoking and IgE sensitisation, are of importance in asthmatic subjects and should be accounted for when interpreting FeNO levels. Furthermore, menarche age and parental smoking during childhood and their effects on lowering FeNO deserve further studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12749","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T12:29:32Z","timestamp":1462278572000},"page":"1185-1193","source":"Crossref","is-referenced-by-count":20,"title":["Important non\u2010disease\u2010related determinants of exhaled nitric oxide levels in mild asthma \u2013 results from the Swedish GA<sup>2<\/sup>LEN study"],"prefix":"10.1111","volume":"46","author":[{"given":"N.","family":"Al\u2010shamkhi","sequence":"first","affiliation":[{"name":"Department of Medical Sciences: Lung\u2010 allergy\u2010 and sleep research Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Dahlen","sequence":"additional","affiliation":[{"name":"Experimental Asthma and Allergy Research Unit Institute of Environmental Medicine Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hedlin","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Middelveld","sequence":"additional","affiliation":[{"name":"Experimental Asthma and Allergy Research Unit Institute of Environmental Medicine Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bjerg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ekerljung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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