{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:02Z","timestamp":1791274442428,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, most studies of the \u2018allergy epidemic\u2019 have been based on self\u2010reported data. There is still limited knowledge on time trends in allergic sensitization, especially among adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study allergic sensitization, its risk factors and time trends in prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within West Sweden Asthma Study (<jats:styled-content style=\"fixed-case\">WSAS<\/jats:styled-content>), a population\u2010based sample of 788 adults (17\u201360 years) underwent skin prick tests (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>s) for 11 aeroallergens 2009\u20132012. Specific IgE was analysed in 750 of the participants. Those aged 20\u201346 years (<jats:italic>n<\/jats:italic> = 379) were compared with the European Community Respiratory Health Survey sample aged 20\u201346 year from the same area (<jats:italic>n<\/jats:italic> = 591) in 1991\u20131992.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among those aged 20\u201346 years, the prevalence of positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> to pollen increased, timothy from 17.1% to 29.0% (<jats:italic>P<\/jats:italic> &lt; 0.001) and birch from 15.6% to 23.7% (<jats:italic>P<\/jats:italic> = 0.002) between 1991\u20131992 and 2009\u20132012. Measurements of specific IgE confirmed these increases. Prevalence of sensitization to all other tested allergens was unchanged. In the full <jats:styled-content style=\"fixed-case\">WSAS<\/jats:styled-content> sample aged 17\u201360 years, any positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> was seen in 41.9%, and the dominating sensitizers were pollen (34.3%), animals (22.8%) and mites (12.6%). Pollen sensitization was strongly associated with rhinitis, whereas indoor allergens were more associated with asthma. Growing up with livestock or furred pets decreased the risk of sensitization, adjusted odds ratio 0.53 (0.28\u20130.995) and 0.68 (0.47\u20130.98), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pollen sensitization has increased in Swedish adults since the early 1990s, while the prevalence of sensitization to other allergens has remained unchanged. This is one plausible explanation for the increase in rhinitis 1990\u20132008 in Swedish adults, during which time the prevalence of asthma, which is more associated with perennial allergens, was stable. Contact with animals in childhood seems to reduce the risk of sensitization well into adulthood. One major factor contributing to the rise in pollen allergy is a significant increase in levels of birch and grass pollen over the past three decades.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12757","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T14:41:05Z","timestamp":1462804865000},"page":"1328-1336","source":"Crossref","is-referenced-by-count":37,"title":["Increase in pollen sensitization in Swedish adults and protective effect of keeping animals in childhood"],"prefix":"10.1111","volume":"46","author":[{"given":"A.","family":"Bjerg","sequence":"first","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Gothenburg University G\u00f6teborg Sweden"},{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ekerljung","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Gothenburg University G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Gothenburg University G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"N\u00e4slund","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Gothenburg University G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sj\u00f6lander","sequence":"additional","affiliation":[{"name":"ImmunoDiagnostics ThermoFisher Scientific Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"R\u00f6nmark","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Gothenburg University G\u00f6teborg Sweden"},{"name":"Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine the OLIN Unit Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Sahlgrenska University Hospital G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wennergren","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Gothenburg University G\u00f6teborg Sweden"},{"name":"Department of Pediatrics Gothenburg University Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tor\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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