{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:14:11Z","timestamp":1764936851690},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical utility of serum periostin as a type 2 biomarker in asthma is limited by lack of reference range values derived from a population without respiratory disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To derive age\u2010 and sex\u2010related reference intervals for serum periostin from an adult population without asthma or <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum periostin levels were measured in 480 individuals, comprising 60 female and 60 male adults in each of the 18\u2010 to 30\u2010year, 31\u2010 to 45\u2010year, 46\u2010 to 60\u2010year and 61\u2010 to 75\u2010year age groups. Key exclusion criteria included a doctor's diagnosis of asthma, chronic bronchitis or <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, and a history of wheezing or use of respiratory inhalers in the last 12 months. The distribution of periostin and logarithm\u2010transformed periostin levels was derived, and 90% confidence intervals for an individual prediction were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of serum periostin was right skewed with a mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) periostin of 51.2 (11.9) ng\/mL, median (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) 50.1 (43.1 to 56.9) ng\/mL and range 28.1 to 136.4 ng\/mL. There was no association between logarithm periostin and age or sex, although levels were low in current smokers. The 90% confidence limits for periostin were 35.0 and 71.1 ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Serum periostin levels in adults without asthma or <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> are similar to those in adults with asthma. Serum periostin measurements do not need to be adjusted to take account of a patient's age or sex, although levels are lower in current smokers. Reference values for serum periostin levels in adults without asthma or <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> are provided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12763","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T07:48:50Z","timestamp":1464594530000},"page":"1303-1314","source":"Crossref","is-referenced-by-count":36,"title":["Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"46","author":[{"given":"R.","family":"Caswell\u2010Smith","sequence":"first","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"},{"name":"Victoria University of Wellington Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hosking","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"},{"name":"University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cripps","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Holweg","sequence":"additional","affiliation":[{"name":"Genentech Inc San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Genentech Inc San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Holliday","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Maillot","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fingleton","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Weatherall","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"},{"name":"University of Otago Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"},{"name":"Victoria University of Wellington Wellington New Zealand"},{"name":"Capital &amp; Coast District Health Board Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand Wellington New Zealand"},{"name":"Victoria University of Wellington Wellington New Zealand"},{"name":"Capital &amp; Coast District Health Board Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Periostin Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.051"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.979"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0392OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.025"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.046"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.021"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707413104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106469"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206719"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1414OC"},{"key":"e_1_2_8_12_1","unstructured":"HorowitzGL AltaieS BoydJC et al.Defining establishing and verifying reference intervals in the clinical laboratory: Approved Guideline \u2013 Third Edition. 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