{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:02:13Z","timestamp":1782475333017,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is widely believed that for allergic rhinitis and asthma, avoidance of specific triggers can improve symptom control. Whilst many children with asthma or rhinitis are sensitized to airborne allergens, primary care diagnostic and management decisions are often made without a detailed history of the allergic triggers or allergy testing. Thus, treatment decisions are empirical and allergen avoidance advice is either not given or, if given, not tailored to the child's sensitivities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To ascertain whether allergy assessment and tailored advice in general practice enhances outcomes of children with asthma and rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Pragmatic <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> of allergy intervention (structured allergy history, skin prick testing and appropriate allergy avoidance advice) vs. usual care in children with asthma and\/or rhinoconjunctivitis. A blinded observer assessed outcomes at 12\u00a0months. Main outcome measures were symptom scores and disease\u2010specific health\u2010related QoL. Secondary outcomes were healthcare utilization, days unable to pursue usual activities and self\u2010rated improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 335 participants were randomized to formal allergy assessment or normal care. There were no differences in participants\u2019 demographic or clinical characteristics at baseline (all <jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). At 12\u00a0months, participants receiving the allergy intervention had fewer rhinitis symptoms (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u2212\u00a03.14, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u2212\u00a06.01, \u2212\u00a00.81) and an improvement in QoL (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u2212\u00a00.50, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.32, 0.68). There were no significant changes in asthma symptoms, healthcare utilization or number of days unable to pursue usual activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amongst children with known asthma and\/or rhinitis in primary care, taking a structured allergy history with skin prick testing and tailored advice on allergy avoidance resulted in reduced symptoms of rhinitis and improved QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12781","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T14:06:40Z","timestamp":1469023600000},"page":"1227-1235","source":"Crossref","is-referenced-by-count":12,"title":["Pragmatic randomized controlled trial of an allergy intervention for children aged 6\u201316 with asthma and rhinitis in general practice"],"prefix":"10.1111","volume":"46","author":[{"given":"H.","family":"Smith","sequence":"first","affiliation":[{"name":"Division of Primary Care and Public Health Brighton and Sussex Medical School Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Horney","sequence":"additional","affiliation":[{"name":"Division of Primary Care and Public Health Brighton and Sussex Medical School Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Primary Care and Public Health Brighton and Sussex Medical School Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Goubet","sequence":"additional","affiliation":[{"name":"Clinical Investigation Research Unit Brighton and Sussex University Hospitals NHS Trust Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Brighton and Sussex Medical School Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Frew","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Respiratory Medicine Royal Sussex County Hospital Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Allergy: The Unmet Need: A Blueprint for Better Patient Care. 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