{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:04Z","timestamp":1791274444374,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010ALIA\u20102012"],"award-info":[{"award-number":["ANR\u201010\u2010ALIA\u20102012"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peanut\u2010allergic reactions are heterogeneous ranging from mild symptoms to anaphylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Identify peanut\u2010allergic\/sensitized phenotypes to personalize patient management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A combined factor and cluster analysis was used to study the phenotypes of 696 patients diagnosed with peanut sensitization and enrolled in the <jats:styled-content style=\"fixed-case\">MIRABEL<\/jats:styled-content> survey. The method was first applied to the 247 patients with an oral food challenge (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>). It was then applied to the 449 patients without <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> to confirm the findings in an independent population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three independent clusters emerged from the <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> subgroup. Cluster 1, \u2018<jats:italic>Severe peanut allergy with little allergic multi\u2010morbidity\u2019<\/jats:italic> (123 subjects), had the highest proportion of patients with positive <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (92%), a medium level of peanut protein inducing a positive <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (235\u00a0mg), lower percentage of allergic multi\u2010morbidity (2% asthma plus atopic dermatitis (A + <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), no cases of A + <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> + multiple food allergies (<jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content>)). Cluster 2, \u2018<jats:italic>Severe peanut allergy with frequent allergic multi\u2010morbidity\u2019<\/jats:italic> (62 subjects), had a high proportion of patients with positive <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (85%) with the lowest level of peanut protein inducing a positive <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (112\u00a0mg), 89% allergic subjects, 100% with allergic multi\u2010morbidity (A + <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) and 84% with A + <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content>. Cluster 3, \u2018<jats:italic>Mild peanut\u2010<\/jats:italic>allergic\/sensitized <jats:italic>phenotype\u2019<\/jats:italic> (62 subjects), had the lowest mean age, the lowest proportion of patients with positive <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (53%) with a high level of peanut protein inducing a positive <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (770\u00a0mg), a low percentage of allergic multi\u2010morbidity (48% A + <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content>). The two severe peanut\u2010allergic phenotypes were more frequent in girls. The same clusters were found in the subgroup of patients without <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Clinical Relevance<\/jats:title><jats:p>Besides the classic markers associated with lower threshold doses of <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> (such as <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">rA<\/jats:styled-content>ra h 2), allergic multi\u2010morbidity and female gender should also be taken into account to better adapt the progressive dosage of provocation tests.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12791","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T14:03:05Z","timestamp":1470924185000},"page":"1596-1604","source":"Crossref","is-referenced-by-count":40,"title":["Three peanut\u2010allergic\/sensitized phenotypes with gender difference"],"prefix":"10.1111","volume":"46","author":[{"given":"J.","family":"Just","sequence":"first","affiliation":[{"name":"Allergology Department Centre de l'Asthme et des Allergies. H\u00f4pital d'Enfants Armand\u2010Trousseau \u2013 26 Paris Cedex 12 France"},{"name":"INSERM UMR_S 1136 Sorbonne Universit\u00e9s UPMC Univ Paris 06 \u2013 Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique Equipe EPAR Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Elegbede","sequence":"additional","affiliation":[{"name":"Risk Assessment Department (DER) French Agency for Food, Environmental and Occupational Health Safety (ANSES) Maisons\u2010Alfort France"},{"name":"French National Institute for Agricultural Research (INRA) Paris Institute of Technology for Life, Food and Environmental Sciences (AgroParisTech) UMR Economie Publique INRA\u2010AgroParisTech Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Deschildre","sequence":"additional","affiliation":[{"name":"Pneumologie et\u00a0allergologie p\u00e9diatriques P\u00f4le enfant H\u00f4pital Jeanne de Flandre University Hospital Universit\u00e9 Lille Nord de France Lille cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bousquet","sequence":"additional","affiliation":[{"name":"CHRU de Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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