{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:10:51Z","timestamp":1773033051425,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["11868"],"award-info":[{"award-number":["11868"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003842","name":"Ilhan Food Allergy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The double\u2010blind, placebo\u2010controlled food challenge test (DBPCFC) is the gold standard in cashew nut allergy. This test is costly, time consuming and not without side effects. Analysis of IgE reactivity to cashew nut components may reduce the need for food challenge tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective and multicentre study, children with suspected cashew nut allergy underwent a DBPCFC with cashew nut. Specific IgE to cashew nut and to the components Ana o 1, 2 and 3 were determined. A skin prick test (SPT) with cashew nut extract was performed.<\/jats:p><jats:p>The association between the outcome of the food challenge test and specific IgE to Ana o 1, 2 and 3 was assessed with logistic regression analyses, unadjusted and adjusted for other diagnostic variables. Discriminative ability was quantified with a concordance index (c).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 173 children (103 boys, 60%) with a median age of 9 years were included. About 79% had a positive challenge test outcome. A steep rise in the risk of a positive challenge was observed for specific IgE to each individual component Ana o 1, 2 and 3 with estimated risks up to approximately 100%. Median values of Ana o 1, 2, 3 were 1.29 kU\/l (range 0\u2013100 kU\/l), 4.77 kU\/l (range 0\u2013100 kU\/l) and 8.33 kU\/l (range 0\u2013100 kU\/l) respectively and varied significantly (<jats:italic>p<\/jats:italic> &lt; 0.001). Specific IgE to Ana o 1, 2 and 3 was better distinguished between cashew\u2010allergic and tolerant children (<jats:italic>c<\/jats:italic> = 0.87, 0.85 and 0.89, respectively) than specific IgE to cashew nut or SPT (<jats:italic>c<\/jats:italic> = 0.76 and 0.83, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The major cashew nut allergens Ana o 1, 2 and 3 are each individually predictive for the outcome of food challenge tests in cashew\u2010allergic children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12794","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T14:12:40Z","timestamp":1470924760000},"page":"113-120","source":"Crossref","is-referenced-by-count":29,"title":["sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts"],"prefix":"10.1111","volume":"47","author":[{"given":"J. P. M.","family":"van der Valk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Allergology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gerth van Wijk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Allergology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Vergouwe","sequence":"additional","affiliation":[{"name":"Center for Medical Decision Making Department of Public Health Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. W.","family":"Steyerberg","sequence":"additional","affiliation":[{"name":"Center for Medical Decision Making Department of Public Health Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reitsma","sequence":"additional","affiliation":[{"name":"Wageningen UR Food &amp; Biobased Research Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Wichers","sequence":"additional","affiliation":[{"name":"Wageningen UR Food &amp; Biobased Research Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. F. J.","family":"Savelkoul","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Immunology Wageningen University Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Vlieg\u2010Boerstra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Onze Lieve Vrouwe Gasthuis (OLVG) Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergology Diaconessenhuis Voorburg RdGG Delft The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E. J.","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergology University Medical Centre Groningen GRIAC Research Institute University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. W.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Allergology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056003252.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00342.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151055"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0554-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.125208"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.12.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073262"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.037"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-016-0092-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02539.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318054b0c3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12437"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b04401"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12530"},{"key":"e_1_2_9_17_1","volume-title":"R: a language and environment for statistical computing","author":"R Foundation for Statistical Computing","year":"2011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.043"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12160"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12075"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.08.010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874091X00802010016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00371.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2004.00188.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01113.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114708"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00928.x"},{"key":"e_1_2_9_28_1","first-page":"24","article-title":"Predictive values for food challenge\u2010induced severe reactions: development of a simple food challenge score","volume":"14","author":"Cianferoni A","year":"2012","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.004"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:06:43Z","timestamp":1696226803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/cea.12794"],"URL":"https:\/\/doi.org\/10.1111\/cea.12794","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}