{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:16:34Z","timestamp":1778811394398,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Monash Lung & Sleep Institute and Monash Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Abnormal vocal cord movements can cause laryngeal extrathoracic airway obstruction (often called vocal cord dysfunction \u2013 VCD<\/jats:styled-content>) leading to asthma\u2010like symptoms. These aberrant movements are characteristically present during inspiration and termed paradoxical vocal cord movement (PVCM<\/jats:styled-content>). We have reported PVCM<\/jats:styled-content> in up to 40% of severe asthmatics, but it is not known if PVCM<\/jats:styled-content> is detectable in all patients with asthma\u2010like symptoms and if the condition is more often associated with abnormal lung function.<\/jats:p><\/jats:sec>Objective<\/jats:title>We hypothesized that PVCM<\/jats:styled-content> is frequently associated with asthma symptoms accompanied by airflow limitation. Studies examined whether PVCM<\/jats:styled-content> is solely linked to experiencing asthma symptoms, or if PVCM<\/jats:styled-content> is related to airflow limitation and\/or other disease characteristics.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with asthma symptoms were recruited from general practice and severe asthma clinics (n<\/jats:italic> = 155). Pulmonary function measurements were conducted, asthma control and Nijmegen (dysfunctional breathing) questionnaires were administered and skin prick testing was carried out. PVCM<\/jats:styled-content> was quantified using dynamic 320\u2010slice computerized tomography of the larynx. Groups were divided into patients with FEV<\/jats:styled-content>1<\/jats:sub> \u2265 80% predicted or FEV<\/jats:styled-content>1<\/jats:sub> < 80% predicted and FEV<\/jats:styled-content>1<\/jats:sub>\/FVC<\/jats:styled-content> < 0.7. ATS<\/jats:styled-content>\/ERS<\/jats:styled-content> definitions of severity were also applied and evaluated. Detection of PVCM<\/jats:styled-content> in the groups was compared and analyses performed to identify features associated with PVCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall (n<\/jats:italic> = 155), PVCM<\/jats:styled-content> was detected in 42 cases (27.1%). Patients with FEV<\/jats:styled-content>1<\/jats:sub> < 80% predicted had PVCM<\/jats:styled-content> more often (25\/68, 36.8%) than individuals with normal spirometry (17\/87, 19.5%; P<\/jats:italic> = 0.016). PVCM<\/jats:styled-content> was associated with older age (P<\/jats:italic> = 0.003) and with Nijmegen scores > 20 (P<\/jats:italic> = 0.04). Patients with FEV<\/jats:styled-content>1<\/jats:sub> < 80% predicted plus Nijmegen scores > 20 were more likely to have PVCM<\/jats:styled-content> (OR<\/jats:styled-content> = 9.3, P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec>Conclusions and Clinical Relevance<\/jats:title>Paradoxical vocal cord movement is more often associated with asthma symptoms accompanied by airflow limitation and dysfunctional breathing. Further studies are needed to determine whether PVCM<\/jats:styled-content> is induced by dysfunctional breathing practices and\/or airway obstruction. How PVCM<\/jats:styled-content> links with symptomatic asthma and VCD<\/jats:styled-content> also requires evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12828","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T15:16:43Z","timestamp":1474730203000},"page":"200-207","source":"Crossref","is-referenced-by-count":50,"title":["Abnormal vocal cord movement in patients with and without airway obstruction and asthma symptoms"],"prefix":"10.1111","volume":"47","author":[{"given":"K.","family":"Low","sequence":"first","affiliation":[{"name":"Monash Lung and Sleep Monash University and Hospital Melbourne Vic. Australia"},{"name":"Hudson Institute Monash University and Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ruane","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash University and Hospital Melbourne Vic. 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