{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:15:26Z","timestamp":1783466126107,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds","doi-asserted-by":"publisher","award":["B\/11005\/02"],"award-info":[{"award-number":["B\/11005\/02"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["A12\/5\u2010HB\u2010KH3"],"award-info":[{"award-number":["A12\/5\u2010HB\u2010KH3"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0436.04"],"award-info":[{"award-number":["G.0436.04"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An important percentage of subjects diagnosed with chronic upper airway disease report alcohol\u2010induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol\u2010containing drinks have not been fully investigated yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to estimate the prevalence and characteristics of alcohol hyper\u2010responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper\u2010responsiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the prevalence and characteristics of alcohol\u2010induced respiratory complaints in 1281 subjects. Chronic rhinosinusitis with nasal polyps (CRSwNP) patients with and without NSAID exacerbated respiratory disease (NERD), chronic rhinosinusitis patients without nasal polyps (CRSsNP), allergic rhinitis (AR) patients and healthy controls were approached by means of a questionnaire. Inflammatory markers (eosinophilic cationic protein (ECP), IL\u20105, IgE, SAE\u2010specific IgE, IL\u201017, TNF\u03b1 and IFN\u03b3) in tissue were then compared between alcohol hyper\u2010responsive and non\u2010hyper\u2010responsive CRSwNP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The highest prevalence of nasal and bronchial alcohol hyper\u2010responsiveness was observed in patients with NERD, followed by CRSwNP, and less frequent in CRSsNP, AR and healthy controls. Alcohol hyper\u2010responsiveness is significantly more prevalent in CRSwNP patients suffering from recurrent disease and in patients with severe symptomatology. In nasal tissue of the hyper\u2010responsive CRSwNP group, we observed significantly higher nasal levels of the eosinophilic biomarker ECP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>Nasal hyper\u2010responsiveness to alcohol is significantly more prevalent in severe eosinophilic upper airway disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12836","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T05:12:46Z","timestamp":1477113166000},"page":"245-253","source":"Crossref","is-referenced-by-count":28,"title":["Alcohol hyper\u2010responsiveness in chronic rhinosinusitis with nasal polyps"],"prefix":"10.1111","volume":"47","author":[{"given":"Els","family":"De Schryver","sequence":"first","affiliation":[{"name":"Upper Airways Research Laboratory Department Otorhinolaryngology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Derycke","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department Otorhinolaryngology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Campo","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica Allergy\u2010IBIMA University Hospital M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Gabriels","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department Otorhinolaryngology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy F.","family":"Joos","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Research in Obstructive Pulmonary diseases Department of Respiratory Medicine Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Van Zele","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department Otorhinolaryngology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department Otorhinolaryngology Ghent University Hospital Ghent Belgium"},{"name":"Division of ENT Diseases Clintec, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Hellings","sequence":"additional","affiliation":[{"name":"Clinical Division of ENT, Head &amp; 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