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Anaphylaxis at age 16\u00a0years was defined per <jats:styled-content style=\"fixed-case\">NIAID<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FAAN<\/jats:styled-content> criteria. Immunoglobulin E (IgE) antibodies to 14 common food and inhalant allergens were analysed at ages 4 (<jats:italic>n<\/jats:italic>\u00a0=\u00a02283) and 16\u00a0years (<jats:italic>n<\/jats:italic>\u00a0=\u00a02510). Among adolescents with food\u2010related symptoms (<jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>) and for whom blood was available (<jats:italic>n<\/jats:italic>\u00a0=\u00a0221), 25 additional food allergen extracts or allergen components were analysed. Associations between reactions to foods, and sensitization and allergic multimorbidity were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 12\u00a0months prior to the 16\u2010year assessment, 8.5% of adolescents had <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>. This included 0.8% (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) adolescents who were classified as having anaphylaxis, yielding an incidence rate of 761\/100\u00a0000 person\u2010years. One\u2010third of adolescents accessed health care during anaphylaxis. Allergic multimorbidity in infancy, as well as sensitization to foods and airborne allergens at age 4\u00a0years, was associated with an increased risk for <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content> in adolescence. Peanuts and tree nuts were the most common culprit foods for anaphylaxis, and fruits and vegetables for non\u2010anaphylactic reactions. Adolescents with anaphylaxis were significantly more likely to be sensitized to storage proteins (Ara h 2, Cor a 9, Cor a 14) and to be polysensitized to foods (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 vs. non\u2010anaphylactic reactions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>The incidence of food\u2010induced anaphylaxis during adolescence in our population\u2010based birth cohort is higher than previously reported. Adolescents with anaphylaxis differ from adolescents with non\u2010anaphylactic <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content> with regard to culprit foods and sensitization. Adolescents with previous anaphylaxis are likely to be polysensitized to foods, particularly tree nut and peanut storage proteins, and which warrants consideration at follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12842","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T12:58:38Z","timestamp":1480424318000},"page":"1575-1587","source":"Crossref","is-referenced-by-count":21,"title":["Anaphylaxis to foods in a population of adolescents: incidence, characteristics and associated risks"],"prefix":"10.1111","volume":"46","author":[{"given":"M.","family":"Vetander","sequence":"first","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Allergy Research Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L. 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