{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:36Z","timestamp":1791274416805,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mono\u2010 and polysensitization are different IgE\u2010mediated allergic phenotypes in children. Allergic sensitization is associated with both allergic asthma and allergic rhinitis, however, associations between the sensitization pattern and particularly polysensitization with asthma and rhinitis remains poorly studied in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to assess how the allergic sensitization pattern associates with asthma, rhinitis and their multimorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      1199 adults from the\n                      <jats:styled-content style=\"fixed-case\">EGEA<\/jats:styled-content>\n                      study, with extensive phenotypic characterization and all data available on skin prick tests to 10 allergens, total IgE and blood eosinophils were included. Using questionnaires only, participants were classified into 6 groups: asymptomatic (no asthma, no rhinitis), non\u2010allergic rhinitis alone, allergic rhinitis alone, asthma alone, asthma+non\u2010allergic rhinitis and asthma+allergic rhinitis. Mono\u2010 and polysensitization were defined by a positive skin prick test to one or more than one allergen respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Asymptomatic participants and those with non\u2010allergic rhinitis alone were mostly non\u2010sensitized (around 72%) while around 12% were polysensitized. Between 32% and 43% of participants with allergic rhinitis alone, asthma alone and asthma+non\u2010allergic rhinitis were non\u2010sensitized and between 37% and 46% of them were polysensitized. 65% of the participants with asthma+allergic rhinitis were polysensitized. The level of total IgE followed a similar trend to that of allergic sensitization. Eosinophils were increased in asthma, especially when associated with rhinitis. Nasal symptoms were more severe and eczema more common in participants with both asthma and allergic rhinitis than in the other groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Allergic sensitization and particularly polysensitization rates widely differ according to asthma and rhinitis status. This study emphasized the importance of taking into account multimorbidity between asthma and rhinitis and showed that allergic sensitization is not a dichotomic variable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.12897","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T15:22:48Z","timestamp":1488036168000},"page":"520-529","source":"Crossref","is-referenced-by-count":65,"title":["The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study"],"prefix":"10.1111","volume":"47","author":[{"given":"E.","family":"Burte","sequence":"first","affiliation":[{"name":"INSERM U1168 VIMA: Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"University of Versailles St\u2010Quentin\u2010en\u2010Yvelines UMR\u2010S 1168 Montigny le Bretonneux France"},{"name":"University of Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bousquet","sequence":"additional","affiliation":[{"name":"INSERM U1168 VIMA: Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"University of Versailles St\u2010Quentin\u2010en\u2010Yvelines UMR\u2010S 1168 Montigny le Bretonneux France"},{"name":"University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Siroux","sequence":"additional","affiliation":[{"name":"INSERM IAB Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health Grenoble France"},{"name":"University of Grenoble Alpes Grenoble France"},{"name":"CHU de Grenoble Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Just","sequence":"additional","affiliation":[{"name":"Allergology Department Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Armand\u2010Trousseau Paris France"},{"name":"Universit\u00e9 Paris 6 Pierre et Marie Curie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Jacquemin","sequence":"additional","affiliation":[{"name":"INSERM U1168 VIMA: Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"University of Versailles St\u2010Quentin\u2010en\u2010Yvelines UMR\u2010S 1168 Montigny le Bretonneux France"},{"name":"University of Pompeu Fabra (UPF) Barcelona Spain"},{"name":"ISGlobal\u2010 CREAL\u2010Centre for Research in Environmental Epidemiology Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nadif","sequence":"additional","affiliation":[{"name":"INSERM U1168 VIMA: Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"University of Versailles St\u2010Quentin\u2010en\u2010Yvelines UMR\u2010S 1168 Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.047"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01715.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12637"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-16"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01048.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2013.00015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.00993.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90397-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12670"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136191"},{"key":"e_1_2_8_15_1","first-page":"343","article-title":"Epidemiological study of the genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA). 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