{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:38:22Z","timestamp":1785753502915,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR\/00034"],"award-info":[{"award-number":["JR\/00034"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The peach non\u2010specific lipid transfer protein, Pru p 3, is the primary sensitizer in fruits and responsible for severe reactions in the Mediterranean area. Peach allergy is frequently associated with other allergies such as peanut. <jats:italic>Therefore<\/jats:italic>, it is important to assess how specific immunotherapy to Pru p 3 could affect both peach and peanut tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate peach and peanut desensitization and immunological changes after 1\u00a0year of Pru p 3 sublingual immunotherapy (<jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>) in patients with systemic allergic reactions to peach and\/or peanut.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight peach allergic patients, 36 treated with <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> and 12 non\u2010treated, were monitored for 12\u00a0months. Treated patients were subclassified as peanut allergic (Group A), sensitized (Group B) or tolerant (Group C). <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> effect was evaluated by skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) reactivity and food challenge. Immunological changes were evaluated by monitoring sIgE and sIgG4 levels and basophil reactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1\u00a0year of <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>, the weal area in <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> significantly decreased and a significant increase in peach threshold in treated patients <jats:italic>was observed<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Patients in Group A showed a significant decrease in peanut <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> weal area and an increase in peanut threshold (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Immunological changes were observed in treated patients only, with a significant decrease in sIgE and a parallel increase in sIgG4, sIgG4\/sIgE and basophil reactivity for both Pru p 3 and Ara h 9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>After 1\u00a0year, Pru p 3 <jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content> induces both desensitization and immunological changes not only for peach but also for other food allergens relevant in the induction of severe reactions such as peanut.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12901","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T14:46:41Z","timestamp":1486219601000},"page":"339-350","source":"Crossref","is-referenced-by-count":78,"title":["The clinical and immunological effects of Pru p 3 sublingual immunotherapy on peach and peanut allergy in patients with systemic reactions"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-6686","authenticated-orcid":false,"given":"F.","family":"Gomez","sequence":"first","affiliation":[{"name":"Allergy Unit IBIMA\u2010Regional University Hospital of Malaga UMA Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bogas","sequence":"additional","affiliation":[{"name":"Allergy Unit IBIMA\u2010Regional University Hospital of Malaga UMA Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Research Laboratory IBIMA\u2010Regional University Hospital of Malaga UMA Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Campo","sequence":"additional","affiliation":[{"name":"Allergy Unit IBIMA\u2010Regional University Hospital of Malaga UMA Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salas","sequence":"additional","affiliation":[{"name":"Allergy Unit IBIMA\u2010Regional University Hospital of Malaga UMA Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diaz\u2010Perales","sequence":"additional","affiliation":[{"name":"Centre for Plant Biotechnology and Genomics (UPM\u2010INIA) Pozuelo de Alarc\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Research Laboratory IBIMA\u2010Regional University Hospital of Malaga UMA Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Pediatric Unit,\u2010Regional University Hospital of Malaga UMA Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Barber","sequence":"additional","affiliation":[{"name":"Institute for Applied Molecular Medicine (IMMA) School of Medicine Universidad CEU San Pablo Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blanca","sequence":"additional","affiliation":[{"name":"Allergy Unit IBIMA\u2010Regional University Hospital of Malaga UMA Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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