{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:01:58Z","timestamp":1783065718078,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scottish Government Chief Scientist Office Applied Research Programme","award":["07\/01"],"award-info":[{"award-number":["07\/01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Comorbidity in people with asthma can significantly increase asthma morbidity and lower adherence to asthma guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to comprehensively measure the prevalence of physical and mental health comorbidities in adults with asthma using a large nationally representative population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional analysis of routine primary care electronic medical records for 1 424 378 adults in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>, examining the prevalence of 39 comorbidities in people with and without asthma, before and after adjustment for age, sex, social deprivation and smoking status using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 39 comorbidities measured, 36 (92%) were significantly more common in adults with asthma; 62.6% of adults with asthma had \u22651 comorbidity vs 46.2% of those without, and 16.3% had \u22654 comorbidities vs 8.7% of those without. Comorbidities with the largest absolute increase in prevalence in adults with asthma were as follows: chronic obstructive pulmonary disease (COPD) (13.4% vs 3.1%), depression (17.3% vs 9.1%), painful conditions (15.4% vs 8.4%) and dyspepsia (10.9% vs 5.2%). Comorbidities with the largest relative difference in adults with asthma compared to those without were as follows: <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> (adjusted odds ratio [<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>] 5.65, 95% CI 5.52\u20105.79), bronchiectasis (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 4.65, 95% CI 4.26\u20105.08), eczema\/psoriasis (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 3.30, 95% CI 3.14\u20103.48), dyspepsia (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 2.20, 95% CI 2.15\u20102.25) and chronic sinusitis (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 2.12, 95% CI 1.99\u20102.26). Depression and anxiety were more common in adults with asthma (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 1.60, 95% CI 1.57\u20101.63, and <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 1.53, 95% CI 1.48\u20101.57, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Physical and mental health comorbidities are the norm in adults with asthma. Appropriate recognition and management should form part of routine asthma care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12971","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T14:58:46Z","timestamp":1498834726000},"page":"1246-1252","source":"Crossref","is-referenced-by-count":63,"title":["Comorbidities in adults with asthma: Population\u2010based cross\u2010sectional analysis of 1.4 million adults in Scotland"],"prefix":"10.1111","volume":"47","author":[{"given":"C. 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