{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:49:35Z","timestamp":1769381375084,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Workers exposed to laboratory animals have a high risk of developing laboratory animal allergy (<jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content>). Atopy seems to be the main risk factor for <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content>. We hypothesized that occupational sensitization is a better predictor for the development of asthma, rhinitis, and bronchial hyperresponsiveness (BHR) than common sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between occupational sensitization to laboratory animals and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study performed at two universities on students and employees dealing with small rodents. The subjects were allocated in groups: non\u2010sensitized, common sensitization, or occupational sensitization, according to the results of the skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>). All subjects answered a questionnaire about animal exposures, symptoms, allergic diseases, and underwent spirometry and bronchial challenge test with mannitol. Multivariate analysis was performed using Poisson regression to estimate the prevalence ratio (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 453 volunteers were analysed. Non\u2010sensitized group comprised 237 subjects; common sensitization group, 142 subjects; and occupational sensitization group, 74 subjects. Occupational sensitization was associated with greater risk for all outcomes studied. When the common sensitization group was reference, skin symptoms had <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> of 1.36, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.01\u20101.85; wheezing had <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> of 1.75, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95%: 1.21\u20102.53; rhinitis had <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> of 1.25, 95%: 1.11\u20101.40; nocturnal dyspnoea had <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> of 2.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.31\u20104.40; bronchial hyperresponsiveness (BHR) had <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> of 2.47, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.50\u20104.09; and confirmed asthma had <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> of 2.65, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.45\u20104.85. In addition, the overlap of asthma, rhinitis, and skin symptoms in a same subject was significantly more prevalent in the occupational sensitization group, 16.2% versus 4.9% in the common sensitization group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>Occupational sensitization is associated with allergic symptoms and respiratory diseases. <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> with occupational allergens along with other parameters may contribute to detection of risk for allergic and respiratory diseases associated with exposure to laboratory animals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12994","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T23:46:54Z","timestamp":1502236014000},"page":"1436-1444","source":"Crossref","is-referenced-by-count":12,"title":["Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens"],"prefix":"10.1111","volume":"47","author":[{"given":"C. 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