{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:05:13Z","timestamp":1776197113250,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholinergic urticaria (CholU) is a common skin disease characterized by the development of pinpoint\u2010sized weals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. As of now, it is unclear whether patients of different age show differences in the clinical manifestation of CholU, duration of disease, comorbidities or response to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we analysed the demographic data and clinical characteristics including disease duration and comorbidities of 200 patients with CholU, 12\u201076 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified two distinct types of CholU, one with early onset (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>, 71%) and one with late onset (<jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content>, 29%). Patients with <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content> CholU markedly differ in key characteristics: patients with <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>, who had a disease onset before the age of 36, showed no gender preponderance and had a significantly higher rate of concomitant atopic dermatitis (16.9% vs 5.2%; <jats:italic>P<\/jats:italic> = .028) and higher IgE levels (295.5 vs 267.1 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/mL; <jats:italic>P<\/jats:italic> = .020) as compared to patients with <jats:styled-content style=\"fixed-case\">LO<\/jats:styled-content>, who were mainly female (69%), had a shorter duration of disease (33.3 vs 63.7 months; <jats:italic>P<\/jats:italic> = .005), a higher rate of concomitant other forms of urticaria (48.3% vs 33.1%; <jats:italic>P<\/jats:italic> = .044) and a higher rate of psychiatric comorbidities (12.1% vs 1.4%; <jats:italic>P<\/jats:italic> = .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are two subtypes of CholU patients with different gender ratios, disease duration and comorbidities. These findings suggest that two distinct underlying pathogenetic pathways are relevant in these two subgroups of patients with CholU.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13023","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T15:04:41Z","timestamp":1504623881000},"page":"1609-1614","source":"Crossref","is-referenced-by-count":33,"title":["Cholinergic urticaria patients of different age groups have distinct features"],"prefix":"10.1111","volume":"47","author":[{"given":"A.","family":"Asady","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ruft","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin 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