{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:02Z","timestamp":1740126122342,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have reached conflicting conclusions about the role of atopy as a risk factor for COPD. In part, this is attributable to variation in the definitions of airflow limitation and the treatment of people with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish whether there is any independent association between atopy and post\u2010bronchodilator airflow limitation in the general population aged 40 years and over.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional survey was conducted in a general population sample of 2415 people aged 40 years and over in Australia. A history of ever being diagnosed with asthma was elicited by questionnaire. Atopy was defined as any skin prick test weal to common aeroallergens \u22654\u00a0mm. Airflow limitation was defined as post\u2010bronchodilator spirometric (FEV<jats:sub>1<\/jats:sub>\/FVC) ratio &lt;lower limit of normal. Analyses were adjusted for potential confounding due to age, sex, smoking, race and socio\u2010economic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of atopy, ever diagnosed asthma and post\u2010bronchodilator airflow obstruction was 44.8%, 19.3% and 7.5%, respectively. In the population as a whole, atopy was associated with lower FEV\u2081 (adjusted difference \u22120.068L, 95% confidence interval (CI) \u22120.104 to \u22120.032), FVC (adj. difference \u22120.043L, 95% CI \u22120.086 to \u22120.0009) and post\u2010bronchodilator FEV\u2081\/FVC ratio (adj. difference \u22120.011, 95% CI \u22120.017 to \u22120.0055). The effect of atopy on lung function was no longer apparent when participants who reported ever diagnosed asthma were excluded (FEV\u2081 \u22120.011L, [95% CI \u22120.05 to 0.028L], FVC \u22120.012L [95% CI \u22120.060 to 0.036] and FEV\u2081\/FVC ratio \u22120.0012 [95% CI \u22120.0072 to 0.0047L]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>The apparent association between atopy and post\u2010bronchodilator airflow limitation in the general population appears to be explained by the association between atopy and having ever diagnosed asthma and the effect of asthma on lung function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13038","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T15:46:46Z","timestamp":1507045606000},"page":"1625-1630","source":"Crossref","is-referenced-by-count":2,"title":["Atopy in people aged 40\u00a0years and over: Relation to airflow limitation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-2873","authenticated-orcid":false,"given":"E. M.","family":"Guevara\u2010Rattray","sequence":"first","affiliation":[{"name":"Respiratory Sleep and Environmental Health Ingham Institute of Applied Medical Research Sydney NSW Australia"},{"name":"Respiratory and Environmental Epidemiology Woolcock Institute of Medical Research The University of Sydney NSW Australia"},{"name":"South Western Sydney Clinical School University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. L.","family":"Garden","sequence":"additional","affiliation":[{"name":"Respiratory Sleep and Environmental Health Ingham Institute of Applied Medical Research Sydney NSW Australia"},{"name":"South Western Sydney Clinical School University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Physiology and Sleep Medicine Sir Charles Gairdner Hospital Nedlands WA Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wood\u2010Baker","sequence":"additional","affiliation":[{"name":"School of Medicine University of Tasmania Hobart TAS Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Johns","sequence":"additional","affiliation":[{"name":"University of Tasmania Hobart TAS Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sonia Buist","sequence":"additional","affiliation":[{"name":"Pulmonary&amp; Critical Care Medicine Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G. J.","family":"Burney","sequence":"additional","affiliation":[{"name":"Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Haydn Walters","sequence":"additional","affiliation":[{"name":"Faculty of Health University of Tasmania Hobart TAS Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7375-0019","authenticated-orcid":false,"given":"B. G.","family":"Toelle","sequence":"additional","affiliation":[{"name":"Woolcock Emphysema Centre Woolcock Institute of Medical Research The University of Sydney NSW Australia"},{"name":"Sydney Local Health District NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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