{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:14:58Z","timestamp":1792149298159,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Realm Therapeutics Inc., PA, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>It has been reported that topical hypochlorous acid (HOC<\/jats:styled-content>l) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear.<\/jats:p><\/jats:sec>Objective<\/jats:title>To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOC<\/jats:styled-content>l's mode of action.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this study, the effects of topical administration of HOC<\/jats:styled-content>l hydrogel (0.05%) on atopic dermatitis\u2010like lesions in NC<\/jats:styled-content>\/Nga mice model as well as in vitro effects of HOC<\/jats:styled-content>l on dorsal root ganglia neurons and mouse bone marrow\u2010derived dendritic cells (mBMDC<\/jats:styled-content>s) were investigated. NC<\/jats:styled-content>\/Nga mice were sensitized with house dust mite allergen and treated topically with HOC<\/jats:styled-content>l hydrogel both preventively and therapeutically against established lesions. Allergen challenge was continued during HOC<\/jats:styled-content>l hydrogel application.<\/jats:p><\/jats:sec>Results<\/jats:title>Treatment with HOC<\/jats:styled-content>l hydrogel prevented the development of lesions and scratching bouts during the whole observation period. When administered after full development of lesions, HOC<\/jats:styled-content>l reduced lesions and scratching behaviour to a similar extent as a positive control 0.1% betamethasone dipropionate ointment. The reduced inflammatory response by HOC<\/jats:styled-content>l treatment was demonstrated by reduced secretion of inflammatory cytokines in affected skin tissue from NC<\/jats:styled-content>\/Nga mice. In addition, HOC<\/jats:styled-content>l significantly reduced IL<\/jats:styled-content>\u201012 production in mBMDC<\/jats:styled-content>. The diminished scratching behaviour was confirmed by impaired response to several pruritogens in dorsal root ganglia neurons excised from NC<\/jats:styled-content>\/Nga mice after termination of the studies. The response to the stimuli was also reduced by pre\u2010incubation of sensory neurons from untreated BALB<\/jats:styled-content>\/c mice with 0.0001% HOC<\/jats:styled-content>l.<\/jats:p><\/jats:sec>Conclusions and Clinical Relevance<\/jats:title>These data indicate a direct reduction in sensory response by HOC<\/jats:styled-content>l, leading to significantly reduced itch and inflammation in vivo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13045","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T16:26:37Z","timestamp":1507911997000},"page":"78-88","source":"Crossref","is-referenced-by-count":68,"title":["Hypochlorous acid is antipruritic and anti\u2010inflammatory in a mouse model of atopic dermatitis"],"prefix":"10.1111","volume":"48","author":[{"given":"T.","family":"Fukuyama","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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