{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:26:26Z","timestamp":1784744786140,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["440076"],"award-info":[{"award-number":["440076"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Viral aetiology of infection has a significant role in the long\u2010term outcome of early\u2010childhood wheezing.<\/jats:p><\/jats:sec>Objective<\/jats:title>This study examines asthma and lung function in adulthood after early\u2010childhood wheezing induced by respiratory syncytial virus (RSV<\/jats:styled-content>) and rhinovirus (RV<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland). Adenovirus, influenza A and B virus, parainfluenza (1\u20103) virus, and RSV<\/jats:styled-content> were tested on admission using antigen detection and antibody assays, and RSV<\/jats:styled-content> and RV<\/jats:styled-content> were tested by polymerase chain reaction (PCR<\/jats:styled-content>). In 2010, 49 cases and 60 population controls attended a follow\u2010up study, which included spirometry with bronchodilation test and fractionally exhaled nitric oxide (FENO<\/jats:sub><\/jats:styled-content>) measurements.<\/jats:p><\/jats:sec>Results<\/jats:title>Current asthma was present in 64% of the cases with RV<\/jats:styled-content>\u2010induced wheezing (OR<\/jats:styled-content> 17.0 [95%CI<\/jats:styled-content> 3.9\u201075.3] vs controls), in 43% of the cases with RSV<\/jats:styled-content>\u2010induced wheezing episode (6.1 [1.5\u201024.9] vs controls), and in 12% of the controls. The RV<\/jats:styled-content> group showed significantly higher mean FENO<\/jats:sub><\/jats:styled-content> values than the RSV<\/jats:styled-content> group and controls. RV<\/jats:styled-content>\u2010positive cases had lower MEF<\/jats:styled-content>50 before bronchodilation and higher MEF<\/jats:styled-content>50, FEV<\/jats:styled-content>1, and FEV<\/jats:styled-content>1\/FVC<\/jats:styled-content> bronchodilation responses than controls. RSV<\/jats:styled-content>\u2010positive cases had lower FVC<\/jats:styled-content> than controls before bronchodilation.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Cases with RV<\/jats:styled-content>\u2010 and RSV<\/jats:styled-content>\u2010induced early\u2010childhood wheezing had increased risk for asthma in adulthood, and RV<\/jats:styled-content>\u2010positive cases had significantly higher FENO<\/jats:sub><\/jats:styled-content> values than RSV<\/jats:styled-content>\u2010positive cases and controls. Compared to controls, RV<\/jats:styled-content>\u2010positive cases showed more bronchial reactivity, and RSV<\/jats:styled-content>\u2010positive cases showed lower FVC<\/jats:styled-content> before bronchodilation in lung function testing.<\/jats:p><\/jats:sec>Clinical relevance<\/jats:title>Children with RV<\/jats:styled-content>\u2010 or RSV<\/jats:styled-content>\u2010induced wheezing in early childhood have an increased risk for asthma and lung function abnormalities in adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13062","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T07:12:49Z","timestamp":1510816369000},"page":"138-146","source":"Crossref","is-referenced-by-count":37,"title":["Asthma and lung function in adulthood after a viral wheezing episode in early childhood"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-407X","authenticated-orcid":false,"given":"K.","family":"Backman","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ollikainen","sequence":"additional","affiliation":[{"name":"Child Welfare Clinic and School Health Care Health Care Center, Pediatrics Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Piippo\u2010Savolainen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nuolivirta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sein\u00e4joki Central Hospital Sein\u00e4joki 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