{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:53:31Z","timestamp":1792666411994,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peanut allergy necessitates dietary restrictions, preferably individualized by determining reactivity threshold through an oral food challenge (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>). However, risk of systemic reactions often precludes <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> in children with severe peanut allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine whether clinical and\/or immunological characteristics were associated with reactivity threshold in children with anaphylaxis to peanut and secondarily, to investigate whether these characteristics were associated with severity of the allergic reaction during <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blinded placebo\u2010controlled food challenge (<jats:styled-content style=\"fixed-case\">DBPCFC<\/jats:styled-content>) with peanut was performed in 96 5\u2010 to 15\u2010year\u2010old children with a history of severe allergic reactions to peanut and\/or sensitization to peanut (skin prick test [<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>] \u22653 mm or specific immunoglobulin E [s\u2010IgE] \u22650.35 <jats:styled-content style=\"fixed-case\">kUA<\/jats:styled-content>\/L). Investigations preceding the <jats:styled-content style=\"fixed-case\">DBPCFC<\/jats:styled-content> included a structured interview, <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>, lung function measurements, serological immunology assessment (IgE, IgG and IgG<jats:sub>4<\/jats:sub>), basophil activation test (<jats:styled-content style=\"fixed-case\">BAT<\/jats:styled-content>) and conjunctival allergen provocation test (<jats:styled-content style=\"fixed-case\">CAPT<\/jats:styled-content>). International standards were used to define anaphylaxis and grade the allergic reaction during <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During <jats:styled-content style=\"fixed-case\">DBPCFC<\/jats:styled-content>, all 96 children (median age 9.3, range 5.1\u201015.2) reacted with anaphylaxis (moderate objective symptoms from at least two organ systems). Basophil activation (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>63<jats:sup>+<\/jats:sup> basophils \u226515%), peanut <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and the ratio of peanut s\u2010IgE\/total IgE were significantly associated with reactivity threshold and lowest observed adverse events level (<jats:styled-content style=\"fixed-case\">LOAEL<\/jats:styled-content>) (all <jats:italic>P<\/jats:italic> &lt; .04). Basophil activation best predicted very low threshold level (&lt;3 mg of peanut protein), with an optimal cut\u2010off of 75.8% giving a 93.5% negative predictive value. None of the characteristics were significantly associated with the severity of allergic reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>In children with anaphylaxis to peanut, basophil activation, peanut <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and the ratio of peanut s\u2010IgE\/total IgE were associated with reactivity threshold and <jats:styled-content style=\"fixed-case\">LOAEL<\/jats:styled-content>, but not with allergy reaction severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13078","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:21:12Z","timestamp":1514506872000},"page":"415-423","source":"Crossref","is-referenced-by-count":34,"title":["Predicting reactivity threshold in children with anaphylaxis to peanut"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-0607","authenticated-orcid":false,"given":"T.","family":"Reier\u2010Nilsen","sequence":"first","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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C.","family":"L\u00f8drup Carlsen","sequence":"additional","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010H.","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mowinckel","sequence":"additional","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. 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