{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:55:55Z","timestamp":1777262155491,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008575","name":"Allergia- ja Astmaliitto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008575","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003756","name":"Biomedicum Helsinki-s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nut allergy varies from pollen cross\u2010allergy, to primary severe allergy with life\u2010threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species\u2010specific and cross\u2010reactive allergens, is made possible via microarray analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to study the association of variable IgE sensitization profiles to clinical response in peanut\u2010challenged children and adolescents in a birch\u2010endemic region. In addition, we studied the avoidance of tree nuts and species\u2010specific sensitizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied 102 peanut\u2010sensitized patients who underwent a double\u2010blind placebo\u2010controlled challenge to peanut. We analysed\n                      <jats:styled-content style=\"fixed-case\">ISAC<\/jats:styled-content>\n                      Immuno\n                      <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\n                      microarray to 112 allergens, singleplex Immuno\n                      <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\n                      s for hazelnut Cor a 14 and cashew Ana o 3, and performed skin prick tests to peanut, tree nuts and sesame seed. We surveyed avoidance diets with a questionnaire.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sensitization to\n                      <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                      \u201010 proteins was frequent (Bet v 1 90%), but equally high in the challenge negatives and positives. IgE to Ara h 2 and Ara h 6 discriminated peanut allergic (n\u00a0=\u00a069) and tolerant (n\u00a0=\u00a033) the best. Avoidance of tree nuts was common (52% to 96%), but only 6% to 44% presented species\u2010specific sensitizations to tree nuts, so a great number could potentially introduce these species into their diet.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical relevance<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                      \u201010\u2010sensitizations were frequent and strong regardless of peanut allergy status. Component\u2010resolved diagnostics can be employed to demonstrate to patients that sensitization to seed storage proteins of tree nuts is uncommon. Several tree nuts could potentially be reintroduced to the diet.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.13101","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T15:21:30Z","timestamp":1517239290000},"page":"712-721","source":"Crossref","is-referenced-by-count":34,"title":["Component\u2010resolved diagnostics demonstrates that most peanut\u2010allergic individuals could potentially introduce tree nuts to their diet"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-2770","authenticated-orcid":false,"given":"R.","family":"Uotila","sequence":"first","affiliation":[{"name":"Helsinki University Hospital University of Helsinki Helsinki Finland"},{"name":"Skin and Allergy Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Kukkonen","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital University of Helsinki Helsinki Finland"},{"name":"Skin and Allergy Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Blom","sequence":"additional","affiliation":[{"name":"The Netherlands Organisation for Applied Scientific Research (TNO) Zeist The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Remington","sequence":"additional","affiliation":[{"name":"The Netherlands Organisation for Applied Scientific Research (TNO) Zeist The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Westerhout","sequence":"additional","affiliation":[{"name":"The Netherlands Organisation for Applied Scientific Research (TNO) Zeist The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Pelkonen","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital University of Helsinki Helsinki Finland"},{"name":"Skin and Allergy Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital University of Helsinki Helsinki Finland"},{"name":"Skin and Allergy Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.10.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12826"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01191.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12412"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2733-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12671"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8355-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.11.039"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12299"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.07.010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874091X00802010016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02312.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.02.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12075"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371422"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12047"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.034"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12259"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.028"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.00997.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.07.023"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12267"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12693"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12626"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13353"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.09.012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12720"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12466"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.13101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.13101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T07:58:04Z","timestamp":1694937484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.13101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/cea.13101"],"URL":"https:\/\/doi.org\/10.1111\/cea.13101","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732579934.793551861","asserted-by":"object"}]},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]}}}