{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:25:06Z","timestamp":1781645106404,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholinergic urticaria (CholU), a common form of chronic inducible urticaria, is characterized by itchy weals that occur in response to physical exercise or passive warming. CholU patients frequently exhibit a high burden of disease. As of yet, no specific instrument is available to assess their disease\u2010related quality\u2010of\u2010life (QoL) impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to develop and validate the first disease\u2010specific QoL instrument for CholU patients, the Cholinergic Urticaria Quality\u2010of\u2010Life Questionnaire (CholU\u2010QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a combined approach of the literature search, semistructured patient interviews and expert opinion, we developed 96 potential CholU\u2010QoL items. Subsequent item selection was performed by means of impact analysis complemented by an expert review for face validity. The resulting final CholU\u2010QoL was then tested for levels of validity, reliability and influence factors in 88 CholU patients. In parallel, an <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> American\u2010Canadian English version of the CholU\u2010QoL was developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final 28\u2010item CholU\u2010QoL was found to have a 5\u2010domain structure (\u201csymptoms,\u201d \u201cfunctional life,\u201d \u201csocial interaction,\u201d \u201ctherapy,\u201d \u201cemotions\u201d) with excellent internal consistency. The CholU\u2010QoL also showed a valid total score, and good levels of convergent validity, known\u2010groups validity, as well as test\u2010retest reliability. Multiple regression analysis found no significant drivers of the CholU\u2010QoL total score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>The CholU\u2010QoL is the first disease\u2010specific QoL instrument for CholU and also the first specific QoL measure in the field of chronic inducible urticarias. It may serve as a valuable tool for clinical trials and improve routine patient management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13102","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T15:54:54Z","timestamp":1516895694000},"page":"433-444","source":"Crossref","is-referenced-by-count":53,"title":["Development and validation of the Cholinergic Urticaria Quality\u2010of\u2010Life Questionnaire (CholU\u2010QoL)"],"prefix":"10.1111","volume":"48","author":[{"given":"J.","family":"Ruft","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Asady","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Staubach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Urticaria Center of Reference and Excellence (UCARE) University Medical Center Mainz Mainz RP Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Casale","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sussmann","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy Urticaria Center of Reference and Excellence (UCARE) University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Zuberbier","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-481X","authenticated-orcid":false,"given":"M.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4437-0313","authenticated-orcid":false,"given":"K.","family":"Weller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-385X","authenticated-orcid":false,"given":"S.","family":"Altrichter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Urticaria Center of Reference and Excellence (UCARE) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2013.09.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70267-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12884"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED.173.2.217"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12765"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e31825a72fc"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.04.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00833.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01920.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12900"},{"key":"e_1_2_8_13_1","unstructured":"(EMEA) EMA (CHMP) CFMPFHU.Reflection paper on the regulatory guidance for the use of health\u2010related quality of life (HRQL) measures in the evaluation of medicinal products.http:\/\/wwwemaeuropaeu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500003637pdf.2006; Doc. 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