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However, they signal different inflammatory pathways. Simultaneously elevated, they are related to more asthma events in a general population and among younger asthmatics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate if simultaneously elevated Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      and B\u2010Eos relate to asthma outcomes and lung function among subjects with asthma at a wide age span, and how different cut\u2010offs for the markers affect these relations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      , B\u2010Eos and forced expiratory volume in 1 second (\n                      <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>\n                      <jats:sub>1<\/jats:sub>\n                      ) were assessed in 1419 subjects with asthma, aged 6\u201079 years old, from the National Health and Nutrition Examination Survey (\n                      <jats:styled-content style=\"fixed-case\">NHANES<\/jats:styled-content>\n                      ) 2007\u201012. Elevated levels were defined as Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      \u226520 p.p.b. for children &lt;12 years and \u226525 p.p.b. for subjects \u226512 years and B\u2010Eos count \u2265300 cells\/\u03bcL. Additional analyses were performed for the cut\u2010offs Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      &gt;35\/30 and &gt;50\/35 p.p.b., and for B\u2010Eos \u2265400 and \u2265 500 cells\/\u03bcL, as well as for different age subgroups (6\u201017, 18\u201044, &gt;44 years old). Asthma events during the past year were self\u2010reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects with simultaneously elevated Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      and B\u2010Eos compared with normal levels of both markers had a higher adjusted odds ratio (\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )) for having\n                      <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>\n                      <jats:sub>1<\/jats:sub>\n                      &lt;80% of predicted (2.15 (1.28\u20103.59), wheeze disturbing sleep (1.88 (1.27, 2.78)) but did not differ regarding asthma attacks past year. Elevated B\u2010Eos, but not Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      , was related to higher\n                      <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\n                      for asthma attack (1.57 (1.14, 2.18) or emergency room (\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      ) visit due to asthma (1.88 (1.33, 2.64) when elevated Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      and elevated B\u2010Eos were studied as independent predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Simultaneously elevated Fe\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      and B\u2010Eos related to reduced lung function in asthmatics, wheezing symptoms, but not to a history of asthma attacks. Asthma attacks and\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      \u2010visit due to asthma were related to increased B\u2010Eos levels.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.13137","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T09:39:49Z","timestamp":1521970789000},"page":"935-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Simultaneously elevated Fe\n                    <scp>NO<\/scp>\n                    and blood eosinophils relate to asthma morbidity in asthmatics from\n                    <scp>NHANES<\/scp>\n                    2007\u201012"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-2718","authenticated-orcid":false,"given":"I.","family":"Mogensen","sequence":"first","affiliation":[{"name":"Department of Medical Sciences: Lung, Allergy and Sleep Research Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Pediatric Research Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7897-1101","authenticated-orcid":false,"given":"T.","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade do Porto &amp; Instituto e Hospital CUF CINTESIS Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade do Porto &amp; Instituto e Hospital CUF CINTESIS Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-6980","authenticated-orcid":false,"given":"C.","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences: Lung, Allergy and Sleep Research Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Malinovschi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences: Clinical Physiology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Global Initiative for Asthma[Web Page].2015[updated 20151111.http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_2015_Aug11.pdf]. 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