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Small interfering<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>experiments were performed in<jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>\u20101 cells and<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010induced<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>model. Immune responses were analysed by enzyme\u2010linked immunosorbent assay, Western blotting, immunoprecipitation, and histological studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thymic stromal lymphopoietin levels and mast cell\u2010derived p56lck activation were elevated in human subjects with<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>, and in<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>mice, exogenous<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>accelerated<jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content>2\u2010allergic inflammatory reactions by up\u2010regulating p56lck and<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6. On the other hand, depletion of<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>, p56lck, and<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6 ameliorated clinical symptoms in<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>mice. The selective inhibitor of p56lck, damnacanthal, inhibits<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, these observations suggest a role for<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>\/p56lck\/<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6 in<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>and offer insight into potential therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13167","type":"journal-article","created":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T08:35:38Z","timestamp":1526114138000},"page":"875-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Src\u2010type tyrosine kinase p56lck is critical for thymic stromal lymphopoietin\u2010induced allergic rhinitis"],"prefix":"10.1111","volume":"48","author":[{"given":"S.\u2010Y.","family":"Nam","sequence":"first","affiliation":[{"name":"The Department of Food Science &amp; 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