{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:37:21Z","timestamp":1782117441796,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Asthma is a chronic respiratory disease without a cure, although there exists spontaneous remission. Genome\u2010wide association (GWA<\/jats:styled-content>) studies have pinpointed genes associated with asthma development, but did not investigate asthma remission.<\/jats:p><\/jats:sec>Objective<\/jats:title>We performed a GWA<\/jats:styled-content> study to develop insights in asthma remission.<\/jats:p><\/jats:sec>Methods<\/jats:title>Clinical remission (ClinR) was defined by the absence of asthma treatment and wheezing in the last year and asthma attacks in the last 3\u00a0years and complete remission (ComR) similarly but additionally with normal lung function and absence of bronchial hyperresponsiveness (BHR<\/jats:styled-content>). A GWA<\/jats:styled-content> study on both ClinR and ComR was performed in 790 asthmatics with initial doctor diagnosis of asthma and BHR<\/jats:styled-content> and long\u2010term follow\u2010up. We assessed replication of the 25 top single nucleotide polymorphisms (SNP<\/jats:styled-content>s) in 2 independent cohorts (total n\u00a0=\u00a0456), followed by expression quantitative loci (eQTL<\/jats:styled-content>) analyses of the 4 replicated SNP<\/jats:styled-content>s in lung tissue and epithelium.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 790 asthmatics, 178 (23%) had ClinR and 55 ComR (7%) after median follow\u2010up of 15.5 (range 3.3\u201047.8) years. In ClinR, 1 of the 25 SNP<\/jats:styled-content>s, rs2740102, replicated in a meta\u2010analysis of the replication cohorts, which was an eQTL<\/jats:styled-content> for POLI<\/jats:styled-content><\/jats:italic> in lung tissue. In ComR, 3 SNP<\/jats:styled-content>s replicated in a meta\u2010analysis of the replication cohorts. The top\u2010hit, rs6581895, almost reached genome\u2010wide significance (P<\/jats:italic>\u2010value 4.68\u00a0\u00d7\u00a010\u22127<\/jats:sup>) and was an eQTL<\/jats:styled-content> for FRS<\/jats:styled-content>2<\/jats:italic> and CCT<\/jats:styled-content><\/jats:italic> in lung tissue. Rs1420101 was a cis\u2010eQTL<\/jats:styled-content> in lung tissue for IL<\/jats:styled-content>1RL<\/jats:styled-content>1<\/jats:italic> and IL<\/jats:styled-content>18R1<\/jats:italic> and a trans\u2010eQTL<\/jats:styled-content> for IL13<\/jats:italic>.<\/jats:p><\/jats:sec>Conclusions and Clinical Relevance<\/jats:title>By defining a strict remission phenotype, we identified 3 SNP<\/jats:styled-content>s to be associated with complete asthma remission, where 2 SNP<\/jats:styled-content>s have plausible biological relevance in FRS<\/jats:styled-content>2<\/jats:italic>, CCT<\/jats:styled-content><\/jats:italic>, IL<\/jats:styled-content>1RL<\/jats:styled-content>1, IL<\/jats:styled-content>18R1<\/jats:italic> and IL<\/jats:styled-content>13<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13181","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T14:31:29Z","timestamp":1526999489000},"page":"1286-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Novel genes and insights in complete asthma remission: A genome\u2010wide association study on clinical and complete asthma remission"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7531-4547","authenticated-orcid":false,"given":"J. M.","family":"Vonk","sequence":"first","affiliation":[{"name":"University of Groningen University Medical Center Groningen Department of Epidemiology Groningen The Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-1744","authenticated-orcid":false,"given":"M. A. E.","family":"Nieuwenhuis","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"},{"name":"University of Groningen University Medical Center Groningen Department of Pulmonology Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N.","family":"Dijk","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"},{"name":"University of Groningen University Medical Center Groningen Department of Pediatric Pulmonology and Pediatric Allergology Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boudier","sequence":"additional","affiliation":[{"name":"INSERM Team of Environmental Epidemiology applied to Reproduction and Respiratory Health IAB Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-7237","authenticated-orcid":false,"given":"V.","family":"Siroux","sequence":"additional","affiliation":[{"name":"INSERM Team of Environmental Epidemiology applied to Reproduction and Respiratory Health IAB Grenoble France"},{"name":"Team of Environmental Epidemiology applied to Reproduction and Respiratory Health IAB Univ. Grenoble Alpes Grenoble France"},{"name":"CHU de Grenoble Team of Environmental Epidemiology applied to Reproduction and Respiratory Health IAB Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-4286","authenticated-orcid":false,"given":"E.","family":"Bouzigon","sequence":"additional","affiliation":[{"name":"UMR\u2010946 Inserm Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Institut Universitaire d'H\u00e9matologie Universit\u00e9 Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-5976","authenticated-orcid":false,"given":"N.","family":"Probst\u2010Hensch","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-5862","authenticated-orcid":false,"given":"M.","family":"Imboden","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-5728","authenticated-orcid":false,"given":"D.","family":"Keidel","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Sin","sequence":"additional","affiliation":[{"name":"St Paul's Hospital The University of British Columbia James Hogg Research Laboratory Vancouver BC Canada"},{"name":"Respiratory Division Department of Medicine University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-3711","authenticated-orcid":false,"given":"Y.","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec Department of Molecular Medicine Laval University Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hao","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van den Berge","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"},{"name":"University of Groningen University Medical Center Groningen Department of Pulmonology Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-3538","authenticated-orcid":false,"given":"A.","family":"Faiz","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"},{"name":"University of Groningen University Medical Center Groningen Department of Pulmonology Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-3252","authenticated-orcid":false,"given":"G. 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