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According to previous studies, the\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 inflammasome is a multi\u2010protein complex known to be associated with many inflammatory conditions. In response to allergens or allergen\/damage\u2010associated molecular signals,\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 changes its conformation to allow the assembly of the\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 inflammasome complex and activates caspase\u20101, which is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101\u03b2 and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201018. Subsequently, active caspase\u20101 cleaves pro\u2010\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101 and pro\u2010\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201018. Recently, accumulating human and mouse experimental evidence has demonstrated that the\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 inflammasome,\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101\u03b2, and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201018 are critically involved in the development of allergic diseases. Furthermore, the application of specific\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 inflammasome inhibitors has been demonstrated in animal models. Therefore, these inhibitors may represent potential therapeutic methods for the management of clinical allergic disorders. This review summarizes findings related to the\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 inflammasome and its related factors and concludes that specific\n                    <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>\n                    3 inflammasome inhibitors may be potential therapeutic agents for allergic diseases.\n                  <\/jats:p>","DOI":"10.1111\/cea.13190","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T05:58:04Z","timestamp":1528955884000},"page":"1080-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["<scp>NLRP<\/scp>\n                    3 inflammasome: A likely target for the treatment of allergic diseases"],"prefix":"10.1111","volume":"48","author":[{"given":"Yichen","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of 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