{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:35Z","timestamp":1787013995706,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Eosinophilic granulomatosis with polyangiitis (\n EGPA<\/jats:styled-content>\n ) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (\n IL<\/jats:styled-content>\n )\u201033, thymic stromal lymphopoietin (\n TSLP<\/jats:styled-content>\n ), and type 2 innate lymphoid cells (\n ILC<\/jats:styled-content>\n 2) are involved in the innate and type 2 immune responses in\n EGPA<\/jats:styled-content>\n . However, the relationships among these molecules and the mechanisms underlying the development of\n EGPA<\/jats:styled-content>\n remain unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n We investigated the relationships among peripheral blood eosinophil count, serum\n IL<\/jats:styled-content>\n \u201033 and\n TSLP<\/jats:styled-content>\n concentration, and peripheral blood\n ILC<\/jats:styled-content>\n 2 count in patients with\n EGPA<\/jats:styled-content>\n , chronic eosinophilic pneumonia (\n CEP<\/jats:styled-content>\n ), or bronchial asthma (\n BA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We recruited 86 patients with\n EGPA<\/jats:styled-content>\n in three groups (remission, relapse, and onset), 25 patients with\n CEP<\/jats:styled-content>\n at active or inactive stages of disease, and 11 patients with\n BA<\/jats:styled-content>\n . In patients with\n EGPA<\/jats:styled-content>\n ,\n CEP<\/jats:styled-content>\n , or\n BA<\/jats:styled-content>\n , serum\n IL<\/jats:styled-content>\n \u201033,\n sST<\/jats:styled-content>\n 2, and\n TSLP<\/jats:styled-content>\n concentrations were determined using\n ELISA<\/jats:styled-content>\n and peripheral blood\n ILC<\/jats:styled-content>\n 2 counts (as Lin\u20101\n \u2212<\/jats:sup>\n CD<\/jats:styled-content>\n 127\n +<\/jats:sup>\n CRTH<\/jats:styled-content>\n 2\n +<\/jats:sup>\n cells) were determined using flow cytometry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Peripheral blood eosinophil count or\n ILC<\/jats:styled-content>\n 2 count, and serum\n sST<\/jats:styled-content>\n 2 or\n TSLP<\/jats:styled-content>\n concentration were higher in patients with\n EGPA<\/jats:styled-content>\n at onset than in those with\n EGPA<\/jats:styled-content>\n at relapse or remission, or in those with\n BA<\/jats:styled-content>\n or\n CEP<\/jats:styled-content>\n . Serum\n IL<\/jats:styled-content>\n \u201033 concentration was higher in patients with\n EGPA<\/jats:styled-content>\n at relapse than in those with\n EGPA<\/jats:styled-content>\n at onset or remission, or in those with\n BA<\/jats:styled-content>\n or\n CEP<\/jats:styled-content>\n . In a logistic regression model,\n EGPA<\/jats:styled-content>\n disease activity was correlated with serum\n IL<\/jats:styled-content>\n \u201033 concentration and peripheral blood\n ILC<\/jats:styled-content>\n 2 count, but not daily systemic and inhaled corticosteroid dose or immunosuppressant use. Eosinophil count was correlated with peripheral blood\n ILC<\/jats:styled-content>\n 2 count and serum\n TSLP<\/jats:styled-content>\n concentration, but not serum\n IL<\/jats:styled-content>\n \u201033 concentration.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Increased peripheral blood\n ILC<\/jats:styled-content>\n 2 count and serum\n IL<\/jats:styled-content>\n \u201033 concentration were associated with disease activity in\n EGPA<\/jats:styled-content>\n . Increases in serum\n IL<\/jats:styled-content>\n \u201033 concentration may indicate the presence of active vasculitis rather than peripheral or tissue eosinophilia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cea.13209","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T09:39:06Z","timestamp":1529141946000},"page":"1305-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-4569","authenticated-orcid":false,"given":"Naomi","family":"Tsurikisawa","sequence":"first","affiliation":[{"name":"Department of Allergy Hiratuska City Hospital Hiratsuka Japan"},{"name":"Department of Allergy and Respirology National Hospital Organization Sagamihara National Hospital Sagamihara 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Hospital Sagamihara Japan"},{"name":"Department of Respirology St. Marianna University School of Medicine Yokohama City Seibu Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Sagamihara National Hospital Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg J","year":"1951","journal-title":"Am J 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