{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:35:36Z","timestamp":1790796936694,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bronchial asthma is traditionally characterized by chronic allergic inflammation, including eosinophilia and elevated Th2 cytokines. Recently, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010derived neutrophil infiltration was shown to correlate with asthma severity and airway remodelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010derived neutrophils in airway remodelling in chronic bronchial asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized house dust mite antigen\u2010induced mouse models of asthma. Intranasal sensitization and chronic antigen challenge caused a mixed allergic inflammation that included eosinophils and neutrophils (Mix\u2010in group). We neutralized <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and fibroblast growth factor (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102) and investigated the mechanism of airway remodelling in the Mix\u2010in group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Mix\u2010in group displayed neutrophilic infiltration and high levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in lung tissue. The Mix\u2010in group also exhibited more bronchial smooth muscle hyperplasia. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 neutralization decreased the magnitude of all of these effects in the Mix\u2010in group. Antibody arrays revealed an increase in <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 in the Mix\u2010in Group relative to the Eo\u2010ip group, and <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 elevation was associated with smooth muscle hypertrophy\/hyperplasia. High concentrations of neutrophil elastase enhanced E\u2010cadherin\/\u03b2\u2010catenin signalling in bronchial epithelial cells. Neutrophil elastase inhibitor treatment decreased <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 production and E\u2010cadherin\/\u03b2\u2010catenin signalling, which inhibited smooth muscle hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\/neutrophil axis may play an important role in airway remodelling by contributing to smooth muscle hypertrophy\/hyperplasia in mixed allergic inflammation and accordingly represents an attractive therapeutic target for severe asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13263","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T10:54:52Z","timestamp":1535799292000},"page":"1715-1725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neutrophils induce smooth muscle hyperplasia via neutrophil 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