{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:40:35Z","timestamp":1778704835705,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize sensitization patterns to furry animal allergen components in Swedish adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the West Sweden Asthma Study, a random population (n\u00a0=\u00a01103) and an asthma sample (n\u00a0=\u00a0769) were tested for allergen sensitization using Phadiatop<jats:sup>\u00ae<\/jats:sup>. Those with IgE\u00a0\u2265\u00a00.35\u00a0kU<jats:sub>A<\/jats:sub>\/L were tested for cat (Fel d 1, 2, and 4), dog (Can f 1, 2, 3, and 5), and horse (Equ c 1) allergen component sensitization. We defined allergen component poly\u2010sensitization patterns, identified data\u2010driven sensitization clusters, described component sensitization overlaps, and assessed determinants of sensitization patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of allergen component sensitization ranged from 0.8% for Fel d 2 and Can f 3 to 8.9% for Fel d 1. The most common dog component was Can f 5 (3.6%); 2.1% were sensitized to Equ c 1. Those sensitized to Fel d 2 and Fel d 4 were commonly sensitized to Fel d 1. The most common dog component overlap was between Can f 1\/Can f 2 and Can f 5. Mono\u2010sensitization was 5.6%, double sensitization 1.5% and poly\u2010sensitization 2.1%. Sensitization was always higher in the asthma than in the random sample. Three sensitization clusters were derived, namely non\u2010sensitized (90% in random vs 66% in asthma sample); Fel d 1\u2010driven sensitized (7% vs 19%); and multi\u2010sensitized (3% vs 15%). Key determinants of sensitization were gender, age, raised on a farm, family history of allergy or asthma, smoking, and occupational exposure to dust or fumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Clinical Relevance<\/jats:title><jats:p>Fel d 1 and Can f 5 are the most common cat and dog components sensitization in this adult Swedish population. Mono\u2010sensitization is more common than poly\u2010sensitization. This detailed characterization highlights the current distribution of furry animal allergen components in Swedish adults, and their impact on clinical outcomes of asthma will be further explored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13355","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T05:50:41Z","timestamp":1548827441000},"page":"495-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Characterization of sensitization to furry animal allergen components in an adult population"],"prefix":"10.1111","volume":"49","author":[{"given":"Shintaro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Division of Allergology and Respiratory Medicine Department of Medicine Showa University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-6089","authenticated-orcid":false,"given":"Bright I.","family":"Nwaru","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine Institute of Medicine University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Ekerljung","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Sj\u00f6lander","sequence":"additional","affiliation":[{"name":"ImmunoDiagnostics Thermo Fisher Scientific Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mincheva","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik P.","family":"R\u00f6nmark","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"R\u00f6nmark","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine The OLIN Unit Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lundb\u00e4ck","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus P.","family":"Borres","sequence":"additional","affiliation":[{"name":"ImmunoDiagnostics Thermo Fisher Scientific Uppsala Sweden"},{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"L\u00f6tvall","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12757"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12397"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12670"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.09.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70287-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.09.025"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034076"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2012.03.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01293.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12364"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016082"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0554-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.05.031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0557-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-94"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029200100103"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.027"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12198"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.046"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02797.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12422"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.052"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12761"},{"issue":"23","key":"e_1_2_9_27_1","first-page":"231","article-title":"EAACI molecular allergology user's guide","volume":"27","author":"Matricardi PM","year":"2016","journal-title":"Pediatr Allergy Immunol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-017-0061-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-016-0163-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.09.002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-16"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.053"},{"key":"e_1_2_9_33_1","first-page":"495","article-title":"In silico analysis of the identity of lipocalin of dog, cat, horse, cow, hamster and hen. Possible role in allergic diseases","volume":"63","author":"S\u00e1nchez A","year":"2016","journal-title":"Rev Alerg Mex"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12439"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.017"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70173-9"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043214"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.026"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12917"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cea.13355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.13355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:28:04Z","timestamp":1694338084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.13355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/cea.13355"],"URL":"https:\/\/doi.org\/10.1111\/cea.13355","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}