{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:09:05Z","timestamp":1790323745321,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["13\u2010BSV5\u20100015\u201002"],"award-info":[{"award-number":["13\u2010BSV5\u20100015\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Goblet cell hyperplasia (<jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>) is a pathological finding classically reported across asthma severity levels and usually associated with smoking. Multiple biological mechanisms may contribute to excessive mucus production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to decipher the clinical meanings and biological pathways related to <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content> in non\u2010smokers with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cough and sputum assessment questionnaire (<jats:styled-content style=\"fixed-case\">CASA<\/jats:styled-content>\u2010Q) responses at entry and 1\u00a0year later were compared to clinical and functional outcomes in 59 asthmatic patients. <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content> was assessed through periodic\u2010acid shift (<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>) staining on endobronchial biopsies obtained at entry in a subset of 32 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodic\u2010acid shift\u2010staining analysis revealed a double wave distribution discriminating patients with (&gt;10% of the epithelial area) or without <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CASA<\/jats:styled-content>\u2010Q scores were mostly driven by overall asthma severity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). <jats:styled-content style=\"fixed-case\">CASA<\/jats:styled-content>\u2010Q scores remained stable at 1\u00a0year and were independently associated with <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> eosinophil content irrespective of the presence of <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content> was unrelated to the presence of bronchiectasis at <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GERD<\/jats:styled-content> or chronic rhinosinusitis, but correlated well with neutrophilic inflammatory patterns observed upon <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> cellular analysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002 at multivariate analysis). <jats:styled-content style=\"fixed-case\">BALF<\/jats:styled-content> bacterial loads were unrelated to <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content> or to <jats:styled-content style=\"fixed-case\">CASA<\/jats:styled-content>\u2010Q.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Goblet cell hyperplasia is disconnected from chronic cough and sputum when assessed by a specific questionnaire. <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content> is related to neutrophilic asthma whereas symptoms are related to airway eosinophilia. The clinical counterpart of <jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content> is unlikely assessed by the <jats:styled-content style=\"fixed-case\">CASA<\/jats:styled-content>\u2010Q.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13359","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T02:29:30Z","timestamp":1549074570000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Goblet cell hyperplasia as a feature of neutrophilic asthma"],"prefix":"10.1111","volume":"49","author":[{"given":"Khuder","family":"Alagha","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pneumologie et Addictologie University of Montpellier  Montpellier France"},{"name":"Aix Marseille University, INSERM INRA, C2VN  Marseille 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