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Maternal venous blood samples in mid\u2010gestation and umbilical cord blood samples at birth were used to determine 25\u2010hydroxyvitamin D concentrations. At age 10\u00a0years, lung function was measured by spirometry, current asthma and physician\u2010diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. We used multivariable regression models to examine associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher 25\u2010hydroxyvitamin D concentrations in mid\u2010gestation were associated with a higher forced vital capacity (FVC), but a lower forced expiratory volume in 1\u00a0second\/FVC (FEV<jats:sub>1<\/jats:sub>\/FVC) and a lower forced expiratory flow after exhaling 75% of FVC (FEF<jats:sub>75<\/jats:sub>) (<jats:italic>Z<\/jats:italic>\u2010score differences [95% CI] 0.02 [0.00, 0.03], \u22120.02 [\u22120.03, \u22120.01] and \u22120.01 [\u20100.03, \u22120.00], respectively, per 10\u00a0nmol\/L 25\u2010hydroxyvitamin D), but not with asthma. Furthermore, higher 25\u2010hydroxyvitamin D concentrations in mid\u2010gestation were associated with an increased risk of inhalant allergy (Odds Ratio [95% CI] 1.07 [1.02, 1.12]), but not with inhalant allergic sensitization. After additional adjustment for child's 25\u2010hydroxyvitamin D concentrations at the age of 6\u00a0years, only the associations of 25\u2010hydroxyvitamin D concentrations in mid\u2010gestation with FEV<jats:sub>1<\/jats:sub>\/FVC and FEF<jats:sub>75<\/jats:sub> remained. We did not find consistent associations of 25\u2010hydroxyvitamin D concentrations at birth with respiratory or allergy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Our results suggest that maternal 25\u2010hydroxyvitamin D concentrations in mid\u2010gestation may influence lung development. The clinical implications of the observed associations remain unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13384","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T21:33:32Z","timestamp":1552512812000},"page":"900-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Maternal and neonatal 25\u2010hydroxyvitamin D concentrations and school\u2010age lung function, asthma and allergy. The Generation R Study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-6287","authenticated-orcid":false,"given":"Sara M.","family":"Mensink\u2010Bout","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0826-9931","authenticated-orcid":false,"given":"Evelien R.","family":"van Meel","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC, University Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trudy","family":"Voortman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin K.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette W.","family":"De Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Allergology Erasmus MC, University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W. 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