{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:32:09Z","timestamp":1790235129127,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An elevated blood eosinophil count when asthma is stable predicts exacerbations and therapeutic response to corticosteroids or biologics targeting eosinophils. Few studies have examined the prognostic value of blood eosinophils measured at exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To elucidate the relationship between a spot blood eosinophil count\u2013measured at the onset of a life\u2010threatening asthma exacerbation\u2013with indices of exacerbation severity and risk of subsequent exacerbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Real\u2010world, retrospective review of all life\u2010threatening asthma cases admitted at 4 public hospitals in Singapore between 2011\u20102015. We assessed the trends and correlations between blood eosinophil count on admission with arterial blood gas values, duration of mechanical ventilation, and risk of death, hypoxic ischemic encephalopathy or respiratory arrest. Risk of future exacerbations among survivors was modelled using Cox regression and survival curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 376 index life\u2010threatening exacerbations with median blood eosinophil count (5\u201095th percentiles) of 0.270\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (0\u20101.410\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L). Arterial pH decreased and PCO<jats:sub>2<\/jats:sub> increased with increasing eosinophil count. Duration of mechanical ventilation and risk of death, hypoxic ischaemic encephalopathy or respiratory arrest did not vary with eosinophils. Among 329 survivors who were followed\u2010up over a median of 52\u00a0months, blood eosinophils \u22651.200\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L was associated with an increased hazard of emergency visits and\/or admissions for asthma (hazard ratio 1.8, 95% confidence interval 1.1\u20102.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study of life\u2010threatening asthma, we found that a spot blood eosinophil count correlates with severity of respiratory failure and predicts risk of subsequent exacerbations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13465","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T19:44:40Z","timestamp":1563306280000},"page":"1578-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Blood eosinophil count correlates with severity of respiratory failure in life\u2010threatening asthma and predicts risk of subsequent exacerbations"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-2507","authenticated-orcid":false,"given":"Anthony C.A.","family":"Yii","sequence":"first","affiliation":[{"name":"Respiratory and Critical Care Medicine Changi General Hospital Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Duke\u2010National University of Singapore Graduate Medical School Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunn\u2010Ren","family":"Tay","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine Changi General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ser Hon","family":"Puah","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Fang","family":"Lim","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Respiratory and Critical Care Medicine National University Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Li","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Respiratory and Critical Care Medicine National University Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Lau","sequence":"additional","affiliation":[{"name":"Duke\u2010National University of Singapore Graduate Medical School Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raeann","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lay\u2010Ping","family":"Neo","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Fan","family":"Chung","sequence":"additional","affiliation":[{"name":"Airways Disease, National Heart and Lung Institute Imperial College London &amp; 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