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Ten days later, test substance(s) were intradermally injected into ear pinnas (elicitation step), and ear swelling was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In wild\u2010type mice, Ni\u00a0+\u00a0LPS or Ni\u00a0+\u00a0IL\u20101\u03b2 injection at sensitization step followed by Ni alone at elicitation step induced Ni allergy. In IL\u20101\u2010KO, injection of Ni\u00a0+\u00a0IL\u20101\u03b2 (but not Ni\u00a0+\u00a0histamine) was required at <jats:italic>both<\/jats:italic> sensitization <jats:italic>and<\/jats:italic> elicitation steps to induce Ni allergy. In HDC\u2010KO, Ni\u00a0+\u00a0IL\u20101\u03b2\u00a0+\u00a0histamine at sensitization step followed by Ni\u00a0+\u00a0histamine at elicitation step induced Ni allergy. In histamine H1 receptor\u2013deficient mice, IL\u20101\u03b2 induced HDC, but was ineffective as an adjuvant for inducing Ni allergy. In wild\u2010type mice, injection into ear pinnas of Ni 10\u00a0mmol\/L alone or Ni 1\u00a0mmol\/L\u00a0+\u00a0LPS induced IL\u20101\u03b2, HDC and a prolonged swelling of ear pinnas. In non\u2010sensitized mice, injection of IL\u20101\u03b2 by itself into ear pinnas in IL\u20101\u2010KO mice induced prolonged ear swelling. Ni augmented IL\u20101 production (both IL\u20101\u03b1 and IL\u20101\u03b2) and HDC induction in wild\u2010type mice sensitized to Ni.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In mice: (a) for inducing Ni allergy, IL\u20101 is essential at <jats:italic>both<\/jats:italic> the sensitization and elicitation steps, and HDC induction is involved in the effect of IL\u20101, (b) stimulation of H1 receptor is also essential for inducing Ni allergy at both sensitization and elicitation steps, and (c) the \u2018sensitization to Ni\u2019 state may be a state where tissues are primed for augmented production of IL\u20101\u03b1 and\/or IL\u20101\u03b2 in response to Ni. (within 300 words, now 300).<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13467","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T06:29:23Z","timestamp":1563604163000},"page":"1362-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin\u20101 and histamine are essential for inducing nickel allergy in mice"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-2454","authenticated-orcid":false,"given":"Kanan","family":"Bando","sequence":"first","affiliation":[{"name":"Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-8615","authenticated-orcid":false,"given":"Toshinobu","family":"Kuroishi","sequence":"additional","affiliation":[{"name":"Division of Oral Immunology, Department of Oral Biology, Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Division of Oral Immunology, Department of Oral Biology, Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Endo","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1111\/j.1365-2222.2007.02705.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1111\/j.1574-695X.2010.00657.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.intimp.2011.05.010"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/j.intimp.2011.07.025"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1177\/0022034514552674"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1111\/j.1365-2133.2010.10016.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1152\/ajplegacy.1959.196.2.295"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1152\/ajplegacy.1968.215.2.472"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1016\/S0140-6736(66)91860-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1016\/0021-8707(61)90049-1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1152\/ajplegacy.1960.198.6.1187"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1152\/ajplegacy.1962.202.1.66"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1152\/physrev.1968.48.1.155"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1097\/00007890-196902000-00002"},{"key":"e_1_2_8_16_1","first-page":"1295","article-title":"Histamine and circulatory homeostasis","volume":"24","author":"Schayer RW","year":"1965","journal-title":"Fedn Proc"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1016\/0006-2952(82)90394-X"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1038\/sj.bjp.0703085"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1016\/S0006-2952(96)00887-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1016\/0006-2952(89)90335-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1016\/S0300-483X(00)00324-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1007\/s000110050624"},{"key":"e_1_2_8_23_1","first-page":"208","article-title":"Histamine\u2010producing cell stimulating factor (HCSF) and interleukin 3 (IL\u20103): evidence for two distinct molecular entities","volume":"136","author":"Dy M","year":"1986","journal-title":"J lmmunol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.4049\/jimmunol.139.11.3710","article-title":"Histamine\u2010producing cell\u2010stimulating activity. 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