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In placebo\u2010controlled trials, omalizumab has been shown to facilitate allergen immunotherapy and increase tolerance to peanut.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We hypothesized that by combining omalizumab with pOIT, and monitor treatment effects with basophil allergen threshold sensitivity tests (CD\u2010sens), peanut allergic patients could safely initiate pOIT and thereafter slowly withdraw omalizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is the 2nd part of a one\u2010armed open phase\u20102 study where peanut allergic adolescents (n\u00a0=\u00a023) started pOIT after an individualized omalizumab treatment. The pOIT dose was increased from 280 to 2800\u00a0mg peanut protein in 8\u00a0weeks followed by an individualized step\u2010wise withdrawal of omalizumab, based on clinical symptoms and CD\u2010sens levels. pOIT continued for 12\u00a0weeks followed by an open peanut challenge. Peanut CD\u2010sens and allergen\u2010binding activity (ABA) and IgE\u2010ab, IgG\u2010ab and IgG4\u2010ab to peanut and its components were measured during the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 23 patients successfully reached the 2800\u00a0mg maintenance dose. Moderate\/systemic allergic reactions were rare while receiving full\u2010dose omalizumab. Eleven of 23 (48%) successfully continued with pOIT after omalizumab was stopped. Compared to treatment failures, median baseline IgE\u2010ab to peanut components Ara h 1\u20103 and CD\u2010sens to peanut were significantly lower among successfully treated patients and IgG4\u2010ab to peanut, Ara h 2 and 6 increased significantly more during treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical relevance<\/jats:title>\n                    <jats:p>This study indicates that omalizumab is an effective adjunctive therapy for initiation and rapid up\u2010dosing of pOIT; however, adverse events from pOIT become more frequent as omalizumab doses are decreased.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical trials registration<\/jats:bold>\n                      : ClinicalTrials.gov; NCT02402231. EudraCT; 2012\u2010005625\u201078.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.13469","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T08:35:09Z","timestamp":1563784509000},"page":"1328-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Individually dosed omalizumab facilitates peanut oral immunotherapy in peanut allergic adolescents"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-6699","authenticated-orcid":false,"given":"Josef","family":"Brandstr\u00f6m","sequence":"first","affiliation":[{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"},{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirja","family":"Vetander","sequence":"additional","affiliation":[{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Center for Allergy Research Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Charlotte","family":"Sundqvist","sequence":"additional","affiliation":[{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Lilja","sequence":"additional","affiliation":[{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"},{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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