{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:36Z","timestamp":1787013996082,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["DEC\u20102013\/09\/B\/NZ5\/00758"],"award-info":[{"award-number":["DEC\u20102013\/09\/B\/NZ5\/00758"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Airway structural changes are important in asthma pathology and require further investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to evaluate which computed tomography (CT) indices, bronchial histological traits, or blood and bronchoalveolar lavage (BAL) biomarkers correlate best with lung function abnormalities in asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 105 white adult asthmatics (53 with a component of fixed airflow obstruction), we determined airway cross\u2010sectional geometry of two proximal (the right upper lobe apical segmental and the left apicoposterior) and two distal (the right and the left basal posterior) bronchi, quantified the low\u2010attenuation lung area (LAA%), and analysed clusters based on airway CT\u2010metrics. We also performed bronchofiberoscopy with BAL and endobronchial biopsy, assessed blood and BAL biomarkers, including interleukin (IL)\u20104, IL\u20105, IL\u20106, IL\u201010, IL\u201012p70, IL\u201017A, IL\u201023, interferon (INF)\u03b3 and periostin, together with circulating a disintegrin and metalloproteinase domain\u2010containing protein (ADAM)33, and investigated interplays between analysed variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with fixed airflow limitation were characterized by lower lumen area and increased wall area and wall thickness ratios in distal airways, accompanied by raised LAA%. They had also higher blood neutrophilia, blood and BAL eosinophilia, increased circulating fibrinogen, periostin, and ADAM33. Blood neutrophilia, serum high density lipoproteins, thyroid\u2010stimulating hormone, and shortened activated partial thromboplastin time were determinants of thicker reticular basement membrane (RBM). BAL eosinophilia was the only positive predictor of collagen I accumulation. Surprisingly, we observed a negative correlation between RBM thickening and collagen I deposit. Cluster analysis based on CT\u2010metrics of the right lower lobe basal posterior bronchus revealed three well\u2010separated clusters similar in age, asthma duration, and BMI, but different in RBM thickness, collagen I accumulation, and inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical relevance<\/jats:title>\n                    <jats:p>\n                      Airway remodelling traits are mainly related to the Th\n                      <jats:sub>2<\/jats:sub>\n                      profile, higher circulating ADAM33, and blood neutrophilia. Lung function abnormalities and RBM thickening correlate better with CT\u2010metrics of distal than proximal airways.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.13501","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T14:40:06Z","timestamp":1568817606000},"page":"15-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The relationship of airway structural changes to blood and bronchoalveolar lavage biomarkers, and lung function abnormalities in asthma"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-3570","authenticated-orcid":false,"given":"Pawel","family":"Kozlik","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Zuk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Bartyzel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Zarychta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"},{"name":"Pulmonary Hospital Zakopane Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Okon","sequence":"additional","affiliation":[{"name":"Department of Pathology Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics and Natural Sciences University of Rzeszow Rzeszow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Bazan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Computational Modelling University of Rzeszow Rzeszow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kosalka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Soja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Musial","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-0963","authenticated-orcid":false,"given":"Stanislawa","family":"Bazan\u2010Socha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440507"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146905"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053381710"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.039"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.053"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2779"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01951.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2683-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.3461"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178217"},{"key":"e_1_2_9_12_1","unstructured":"Global Initiative for Asthma \u2010 Global Initiative for Asthma \u2010 GINA[Internet]. 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