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Incidence, triggers and management of SCARs have not been investigated in large\u2010scale epidemiological studies on children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to collect epidemiological, clinical and aetiological data from children with SCARs referred to our tertiary care paediatric hospital of Florence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2010 to 2018 charts of children with diagnosis of SCAR were reviewed, and data collected during the acute phase and\/or the subsequent allergy evaluation. Patients underwent patch tests, intradermal tests and lymphocyte transformation tests. All children were investigated for infectious diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence of SCARs in hospitalized children was 0.32% over a 9\u2010year period. Fifty\u2010four children were enrolled (31\u00a0M; 23 F; median age 6.5\u00a0years): 17 cases of DRESS, 30 SJS, 3 TEN, 2 AGEP, 1 linear immunoglobulin A bullous disease (LABD) and 1 pemphigus. Twenty\u2010eight out of 54 patients underwent drug allergy investigations, and 50% of them resulted positive. Combining clinical history and results of allergy work\u2010up, 74% SCARs seem to be caused by drugs, 18.6% by both drugs and infections, 3.7% by infections, and 3.7% remained idiopathic. No deaths occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, SCARs incidence is in line with literature data. Drugs were most commonly the leading cause. Management of SCARs requires cooperation among professional figures for an early diagnosis and a prompt treatment. Mortality rate seems to be lower in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13513","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T06:29:18Z","timestamp":1571034558000},"page":"61-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9\u2010year experience in a tertiary care paediatric hospital setting"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-0423","authenticated-orcid":false,"given":"Giulia","family":"Liccioli","sequence":"first","affiliation":[{"name":"Allergy Unit Department of Paediatrics Anna Meyer Children's University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mori","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Paediatrics Anna Meyer 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