{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:27:42Z","timestamp":1791894462283,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of pubertal BMI change in adult\u2010onset concomitant asthma and allergic rhinitis is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated the association of childhood and young adult BMI, and pubertal BMI changes with adult\u2010onset asthma, allergic rhinitis, and concomitant asthma and rhinitis in Swedish men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The BMI Epidemiology Study in Gothenburg, Sweden, comprised of height and weight measures taken from school health records (6.5\u20109.5\u00a0years) and during military conscription (17.5\u201022\u00a0years) for all men born 1945\u20101961 (n\u00a0=\u00a037\u00a0652). Age\u2010adjusted childhood BMI centred at 8\u00a0years and young adult BMI at 20\u00a0years were linked to high quality data on asthma and allergic rhinitis diagnoses from the Swedish National Patient Register.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>High BMI (4th quartile vs the two median quartiles) at 8\u00a0years was associated with increased risk of concomitant asthma and allergic rhinitis (HR 1.45; 95% CI 1.00\u20102.11). Overweight (HR 1.45; 95% CI 1.12\u20101.89) and obesity (HR 1.95; 95% CI 1.08\u20103.54) at 20\u00a0years were associated with increased risk of asthma without concomitant allergic rhinitis as main or auxiliary diagnosis. Pubertal BMI change showed a non\u2010linear association, so that both low (1st quartile vs the two median quartiles) and high pubertal BMI changes were associated with increased risk of asthma (low: HR 1.36; 95% CI 1.11\u20101.68; high: HR 1.32; 95% CI 1.07\u20101.63) and asthma without concomitant allergic rhinitis (low: HR 1.33; 95% CI 1.04\u20101.69; high: HR 1.36; 95% CI 1.07\u20101.74) as a main diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Both low and high pubertal BMI changes are predictors of adult\u2010onset asthma in men, particularly asthma without concomitant allergic rhinitis. Primary prevention of adult\u2010onset asthma requires monitoring of changes in BMI during puberty.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13534","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T06:14:21Z","timestamp":1573884861000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pubertal BMI change and adult\u2010onset asthma in men: Population\u2010based cohort study in Sweden"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-6089","authenticated-orcid":false,"given":"Bright I.","family":"Nwaru","sequence":"first","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg Gothenburg 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