{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T18:06:42Z","timestamp":1772388402411,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously demonstrated that <jats:italic>Mycobacteria tuberculosis<\/jats:italic> chaperonin 60.1 inhibits leucocyte diapedesis and bronchial hyperresponsiveness in a murine model of allergic lung inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, we have investigated the effect of a shorter peptide sequence derived from Cpn 60.1, named IRL201104, on allergic lung inflammation induced by ovalbumin (OVA) in mice and by house dust mite (HDM) in guinea pigs, as well as investigating the action of IRL201104 on human cells in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010treatment of mice or guinea pigs with IRL201104 inhibits the infiltration of eosinophils to the lung, cytokine release, and in guinea pig skin, inhibits allergen\u2010induced vascular permeability. The protective effect of intranasal IRL201104 against OVA\u2010induced eosinophilia persisted for up to 20\u00a0days post\u2010treatment. Moreover, OVA\u2010sensitized mice treated intranasally with 20\u00a0ng\/kg of IRL201104 show a significant increase in the expression of the anti\u2010inflammatory molecule ubiquitin A20 and significant inhibition of the activation of NF\u2010\u03baB in lung tissue. Our results also show that A20 expression was significantly reduced in blood leucocytes and ASM obtained from patients with asthma compared to cells obtained from healthy subjects which were restored after incubation with IRL201104 in vitro, when added alone, or in combination with LPS or TNF\u2010\u03b1 in ASM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that a peptide derived from mycobacterial Cpn60.1 has a long\u2010lasting anti\u2010inflammatory and immunomodulatory activity which may help explain some of the protective effects of TB against allergic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13550","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T07:13:18Z","timestamp":1576566798000},"page":"508-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modulation of allergic inflammation in the lung by a peptide derived from <i>Mycobacteria tuberculosis<\/i> chaperonin 60.1"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-9430","authenticated-orcid":false,"given":"Yanira","family":"Riffo\u2010Vasquez","sequence":"first","affiliation":[{"name":"Sackler Institute of Pulmonary Pharmacology Institute of Pharmaceutical Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Kanabar","sequence":"additional","affiliation":[{"name":"Sackler Institute of Pulmonary Pharmacology Institute of Pharmaceutical Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra D.","family":"Keir","sequence":"additional","affiliation":[{"name":"Sackler Institute of Pulmonary Pharmacology Institute of Pharmaceutical Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8540","authenticated-orcid":false,"given":"Rodrigo R.","family":"e\u2010Lacerda","sequence":"additional","affiliation":[{"name":"Sackler Institute of Pulmonary Pharmacology Institute of Pharmaceutical Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5076-2180","authenticated-orcid":false,"given":"Francis","family":"Man","sequence":"additional","affiliation":[{"name":"Sackler Institute of Pulmonary Pharmacology Institute of Pharmaceutical Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Asthma Care Guy's &amp; St Thomas' NHS Trust London UK"},{"name":"Faculty of Life Sciences and Medicine MRC &amp; Asthma UK Centre Guy's Hospital, King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Corrigall","sequence":"additional","affiliation":[{"name":"Sackler Institute of Pulmonary Pharmacology Institute of Pharmaceutical Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony R. 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