{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:50:05Z","timestamp":1780937405453,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>The clinical relevance of sensitization to <jats:italic>Aspergillus (A) fumigatus<\/jats:italic> in cystic fibrosis (CF) is unclear. Some researchers propose that specific <jats:italic>A fumigatus<\/jats:italic> IgE is an innocent bystander, whereas others describe it as the major cause of TH\u20102\u2010driven asthma\u2010like disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lung function parameters in mild CF patients may be different in patients with and without <jats:italic>A fumigatus<\/jats:italic> sensitization. We aimed to ascertain whether allergen exposure to <jats:italic>A fumigatus<\/jats:italic> by bronchial allergen provocation (BAP) induces TH\u20102 inflammation comparable to an asthma\u2010like disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 35 patients, aged 14.8\u00a0\u00b1\u00a08.5\u00a0years, and 20 healthy controls were investigated prospectively. The patients were divided into two groups: group 1 (n\u00a0=\u00a018): specific (s)IgE negative, and group 2 (n\u00a0=\u00a017): sIgE positive (\u22650.7\u00a0KU\/L) for <jats:italic>A fumigatus<\/jats:italic>. Lung function, exhaled NO, and induced sputum were analysed. All sensitized patients with an FEV1\u00a0&gt;\u00a075% (n\u00a0=\u00a013) underwent BAP with <jats:italic>A fumigatus<\/jats:italic>, and cell counts, and the expression of IL\u20105, IL\u201013, INF\u2010\u03b3, and IL\u20108 as well as transcription factors T\u2010bet, GATA\u20103, and FoxP3, were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lung function parameters decreased significantly compared to controls, but not within the CF patient group. After BAP, 8 of 13 patients (61%) had a significant asthmatic response and increased eNO 24\u00a0hours later. In addition, marked TH\u20102\u2010mediated inflammation involving eosinophils, IL\u20105, IL\u201013, and FoxP3 became apparent in induced sputum cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated the clinical relevance of <jats:italic>A fumigatus<\/jats:italic> for the majority of sensitized CF patients. A distinct IgE\/TH\u20102\u2010dominated inflammation was found in induced sputum after <jats:italic>A fumigatus<\/jats:italic> exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13557","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T12:01:19Z","timestamp":1577707279000},"page":"325-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical relevance of <i>Aspergillus fumigatus<\/i> sensitization in cystic fibrosis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2835-9886","authenticated-orcid":false,"given":"Olaf","family":"Eickmeier","sequence":"first","affiliation":[{"name":"Department for Children and Adolescents Division of Allergology, Pulmonology and Cystic fibrosis Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich 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