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However, within such a therapeutic context real\u2010life investigations are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Therefore, the aim of the present observational study was to evaluate the effects of mepolizumab in allergic and non\u2010allergic subjects with severe eosinophilic asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant clinical, functional, laboratory, and pharmacotherapeutic parameters were assessed in the above patient subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After one year of add\u2010on biological treatment with mepolizumab, our 88 patients experienced a remarkable improvement of their severe asthma, documented by a better symptom control, expressed by a significant improvement in asthma control test (ACT) score. Indeed, the mean value (\u00b1standard deviation) of ACT score increased from 12.55 (\u00b13.724) to 21.08 (\u00b13.358). Moreover, significant improvements were also detected with regard to the median values (interquartile range) of forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>), blood eosinophil numbers, annual rate of disease exacerbations, and daily intake of oral corticosteroids (OCS). In particular, FEV<jats:sub>1<\/jats:sub> enhanced from 1640\u00a0mL (1110\u20102275) to 1920\u00a0mL (1525\u20102615), blood eosinophil count dropped from 711.0 cells\/\u03bcL (500.0\u20101022) to 90.00 cells\/\u03bcL (50.00\u2010117.5), the annual rate of asthma exacerbations decreased from 3.000 (2.000\u20106.000) to 0.000 (0.000\u20101.000), and the daily prednisone intake fell from 6.250\u00a0mg (0.000\u201025.00) to 0.000\u00a0mg (0.000\u20100.000). After one year of mepolizumab treatment, the improvements in clinical, functional, and haematological parameters were quite similar in patient subgroups characterized by skin prick test (SPT) negativity or positivity, respectively. A significant correlation was observed between serum IgE levels and OCS intake decrease (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.2257; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>Hence, our real\u2010life data suggest that mepolizumab can represent a valid add\u2010on therapeutic option for patients with severe eosinophilic asthma, irrespective of IgE serum concentrations, and allergic sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13613","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T15:00:32Z","timestamp":1588172432000},"page":"780-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Real\u2010life evaluation of mepolizumab efficacy in patients with severe eosinophilic asthma, according to atopic trait and allergic 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