{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:27:14Z","timestamp":1791235634795,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In allergology, the intradermal approach is generally used to establish an aetiological diagnosis, with limited experience in specific allergen immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of immunotherapy with an allergen extract of glutaraldehyde\u2010polymerized <jats:italic>Phleum pratense<\/jats:italic>, administered intradermally, in patients with rhinoconjunctivitis sensitized to grass pollen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre, randomized, double\u2010blind, placebo\u2010controlled clinical trial in patients from 12 to 65\u00a0years of age with rhinitis or rhinoconjunctivitis, with or without asthma, due to grass pollen allergy. Patients were divided into three groups and received a total of six doses in a weekly interval, of either placebo; 0.03 or 0.06\u00a0\u03bcg of protein per dose of <jats:italic>P\u00a0pratense<\/jats:italic> allergoid. The primary objective was to evaluate the combined symptoms and medication consumption score (CSMS). The secondary objectives were symptoms and medication, tolerance to the conjunctival provocation test, specific IgE and IgG4 antibodies and the safety profile according to the WAO scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dose of 0.06\u00a0\u03bcg of protein proved to be effective versus the placebo by significantly reducing CSMS and increasing tolerance to the allergenic extract in the conjunctival provocation test, after the first pollen season. This group showed a significant reduction in specific IgE after the second pollen season relative to the baseline. There were no variations in IgG4 levels. Only one grade 2 systemic reaction was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Clinical Relevance<\/jats:title><jats:p>Intradermal immunotherapy with <jats:italic>P\u00a0pratense<\/jats:italic> allergoid has been shown to be effective and safe, reducing CSMS, increasing tolerance to the conjunctival provocation test and reducing IgE levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13740","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T20:41:14Z","timestamp":1600461674000},"page":"1352-1361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intradermal <i>Phleum pratense<\/i> allergoid immunotherapy. 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